Quantification of liver fat with respiratory-gated quantitative chemical shift encoded MRI
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Quantification of liver fat with respiratory-gated quantitative chemical shift encoded MRI. / Motosugi, Utaroh; Hernando, Diego; Bannas, Peter; Holmes, James H; Wang, Kang; Shimakawa, Ann; Iwadate, Yuji; Taviani, Valentina; Rehm, Jennifer L; Reeder, Scott B.
In: J MAGN RESON IMAGING, Vol. 42, No. 5, 11.2015, p. 1241-8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Quantification of liver fat with respiratory-gated quantitative chemical shift encoded MRI
AU - Motosugi, Utaroh
AU - Hernando, Diego
AU - Bannas, Peter
AU - Holmes, James H
AU - Wang, Kang
AU - Shimakawa, Ann
AU - Iwadate, Yuji
AU - Taviani, Valentina
AU - Rehm, Jennifer L
AU - Reeder, Scott B
N1 - © 2015 Wiley Periodicals, Inc.
PY - 2015/11
Y1 - 2015/11
N2 - PURPOSE: To evaluate free-breathing chemical shift-encoded (CSE) magnetic resonance imaging (MRI) for quantification of hepatic proton density fat-fraction (PDFF). A secondary purpose was to evaluate hepatic R2* values measured using free-breathing quantitative CSE-MRI.MATERIALS AND METHODS: Fifty patients (mean age, 56 years) were prospectively recruited and underwent the following four acquisitions to measure PDFF and R2*; 1) conventional breath-hold CSE-MRI (BH-CSE); 2) respiratory-gated CSE-MRI using respiratory bellows (BL-CSE); 3) respiratory-gated CSE-MRI using navigator echoes (NV-CSE); and 4) single voxel MR spectroscopy (MRS) as the reference standard for PDFF. Image quality was evaluated by two radiologists. MRI-PDFF measured from the three CSE-MRI methods were compared with MRS-PDFF using linear regression. The PDFF and R2* values were compared using two one-sided t-test to evaluate statistical equivalence.RESULTS: There was no significant difference in the image quality scores among the three CSE-MRI methods for either PDFF (P = 1.000) or R2* maps (P = 0.359-1.000). Correlation coefficients (95% confidence interval [CI]) for the PDFF comparisons were 0.98 (0.96-0.99) for BH-, 0.99 (0.97-0.99) for BL-, and 0.99 (0.98-0.99) for NV-CSE. The statistical equivalence test revealed that the mean difference in PDFF and R2* between any two of the three CSE-MRI methods was less than ±1 percentage point (pp) and ±5 s(-1) , respectively (P < 0.046).CONCLUSION: Respiratory-gated CSE-MRI with respiratory bellows or navigator echo are feasible methods to quantify liver PDFF and R2* and are as valid as the standard breath-hold technique.
AB - PURPOSE: To evaluate free-breathing chemical shift-encoded (CSE) magnetic resonance imaging (MRI) for quantification of hepatic proton density fat-fraction (PDFF). A secondary purpose was to evaluate hepatic R2* values measured using free-breathing quantitative CSE-MRI.MATERIALS AND METHODS: Fifty patients (mean age, 56 years) were prospectively recruited and underwent the following four acquisitions to measure PDFF and R2*; 1) conventional breath-hold CSE-MRI (BH-CSE); 2) respiratory-gated CSE-MRI using respiratory bellows (BL-CSE); 3) respiratory-gated CSE-MRI using navigator echoes (NV-CSE); and 4) single voxel MR spectroscopy (MRS) as the reference standard for PDFF. Image quality was evaluated by two radiologists. MRI-PDFF measured from the three CSE-MRI methods were compared with MRS-PDFF using linear regression. The PDFF and R2* values were compared using two one-sided t-test to evaluate statistical equivalence.RESULTS: There was no significant difference in the image quality scores among the three CSE-MRI methods for either PDFF (P = 1.000) or R2* maps (P = 0.359-1.000). Correlation coefficients (95% confidence interval [CI]) for the PDFF comparisons were 0.98 (0.96-0.99) for BH-, 0.99 (0.97-0.99) for BL-, and 0.99 (0.98-0.99) for NV-CSE. The statistical equivalence test revealed that the mean difference in PDFF and R2* between any two of the three CSE-MRI methods was less than ±1 percentage point (pp) and ±5 s(-1) , respectively (P < 0.046).CONCLUSION: Respiratory-gated CSE-MRI with respiratory bellows or navigator echo are feasible methods to quantify liver PDFF and R2* and are as valid as the standard breath-hold technique.
KW - Fatty Liver
KW - Female
KW - Humans
KW - Liver
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Prospective Studies
KW - Protons
KW - Reproducibility of Results
KW - Journal Article
U2 - 10.1002/jmri.24896
DO - 10.1002/jmri.24896
M3 - SCORING: Journal article
C2 - 25828696
VL - 42
SP - 1241
EP - 1248
JO - J MAGN RESON IMAGING
JF - J MAGN RESON IMAGING
SN - 1053-1807
IS - 5
ER -