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Quantification of liver fat with respiratory-gated quantitative chemical shift encoded MRI

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Quantification of liver fat with respiratory-gated quantitative chemical shift encoded MRI. / Motosugi, Utaroh; Hernando, Diego; Bannas, Peter; Holmes, James H; Wang, Kang; Shimakawa, Ann; Iwadate, Yuji; Taviani, Valentina; Rehm, Jennifer L; Reeder, Scott B.

in: J MAGN RESON IMAGING, Jahrgang 42, Nr. 5, 11.2015, S. 1241-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Motosugi, U, Hernando, D, Bannas, P, Holmes, JH, Wang, K, Shimakawa, A, Iwadate, Y, Taviani, V, Rehm, JL & Reeder, SB 2015, 'Quantification of liver fat with respiratory-gated quantitative chemical shift encoded MRI', J MAGN RESON IMAGING, Jg. 42, Nr. 5, S. 1241-8. https://doi.org/10.1002/jmri.24896

APA

Motosugi, U., Hernando, D., Bannas, P., Holmes, J. H., Wang, K., Shimakawa, A., Iwadate, Y., Taviani, V., Rehm, J. L., & Reeder, S. B. (2015). Quantification of liver fat with respiratory-gated quantitative chemical shift encoded MRI. J MAGN RESON IMAGING, 42(5), 1241-8. https://doi.org/10.1002/jmri.24896

Vancouver

Motosugi U, Hernando D, Bannas P, Holmes JH, Wang K, Shimakawa A et al. Quantification of liver fat with respiratory-gated quantitative chemical shift encoded MRI. J MAGN RESON IMAGING. 2015 Nov;42(5):1241-8. https://doi.org/10.1002/jmri.24896

Bibtex

@article{3da49d08712143debd5b32f141ed805e,
title = "Quantification of liver fat with respiratory-gated quantitative chemical shift encoded MRI",
abstract = "PURPOSE: To evaluate free-breathing chemical shift-encoded (CSE) magnetic resonance imaging (MRI) for quantification of hepatic proton density fat-fraction (PDFF). A secondary purpose was to evaluate hepatic R2* values measured using free-breathing quantitative CSE-MRI.MATERIALS AND METHODS: Fifty patients (mean age, 56 years) were prospectively recruited and underwent the following four acquisitions to measure PDFF and R2*; 1) conventional breath-hold CSE-MRI (BH-CSE); 2) respiratory-gated CSE-MRI using respiratory bellows (BL-CSE); 3) respiratory-gated CSE-MRI using navigator echoes (NV-CSE); and 4) single voxel MR spectroscopy (MRS) as the reference standard for PDFF. Image quality was evaluated by two radiologists. MRI-PDFF measured from the three CSE-MRI methods were compared with MRS-PDFF using linear regression. The PDFF and R2* values were compared using two one-sided t-test to evaluate statistical equivalence.RESULTS: There was no significant difference in the image quality scores among the three CSE-MRI methods for either PDFF (P = 1.000) or R2* maps (P = 0.359-1.000). Correlation coefficients (95% confidence interval [CI]) for the PDFF comparisons were 0.98 (0.96-0.99) for BH-, 0.99 (0.97-0.99) for BL-, and 0.99 (0.98-0.99) for NV-CSE. The statistical equivalence test revealed that the mean difference in PDFF and R2* between any two of the three CSE-MRI methods was less than ±1 percentage point (pp) and ±5 s(-1) , respectively (P < 0.046).CONCLUSION: Respiratory-gated CSE-MRI with respiratory bellows or navigator echo are feasible methods to quantify liver PDFF and R2* and are as valid as the standard breath-hold technique.",
keywords = "Fatty Liver, Female, Humans, Liver, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies, Protons, Reproducibility of Results, Journal Article",
author = "Utaroh Motosugi and Diego Hernando and Peter Bannas and Holmes, {James H} and Kang Wang and Ann Shimakawa and Yuji Iwadate and Valentina Taviani and Rehm, {Jennifer L} and Reeder, {Scott B}",
note = "{\textcopyright} 2015 Wiley Periodicals, Inc.",
year = "2015",
month = nov,
doi = "10.1002/jmri.24896",
language = "English",
volume = "42",
pages = "1241--8",
journal = "J MAGN RESON IMAGING",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Quantification of liver fat with respiratory-gated quantitative chemical shift encoded MRI

AU - Motosugi, Utaroh

AU - Hernando, Diego

AU - Bannas, Peter

AU - Holmes, James H

AU - Wang, Kang

AU - Shimakawa, Ann

AU - Iwadate, Yuji

AU - Taviani, Valentina

AU - Rehm, Jennifer L

AU - Reeder, Scott B

N1 - © 2015 Wiley Periodicals, Inc.

PY - 2015/11

Y1 - 2015/11

N2 - PURPOSE: To evaluate free-breathing chemical shift-encoded (CSE) magnetic resonance imaging (MRI) for quantification of hepatic proton density fat-fraction (PDFF). A secondary purpose was to evaluate hepatic R2* values measured using free-breathing quantitative CSE-MRI.MATERIALS AND METHODS: Fifty patients (mean age, 56 years) were prospectively recruited and underwent the following four acquisitions to measure PDFF and R2*; 1) conventional breath-hold CSE-MRI (BH-CSE); 2) respiratory-gated CSE-MRI using respiratory bellows (BL-CSE); 3) respiratory-gated CSE-MRI using navigator echoes (NV-CSE); and 4) single voxel MR spectroscopy (MRS) as the reference standard for PDFF. Image quality was evaluated by two radiologists. MRI-PDFF measured from the three CSE-MRI methods were compared with MRS-PDFF using linear regression. The PDFF and R2* values were compared using two one-sided t-test to evaluate statistical equivalence.RESULTS: There was no significant difference in the image quality scores among the three CSE-MRI methods for either PDFF (P = 1.000) or R2* maps (P = 0.359-1.000). Correlation coefficients (95% confidence interval [CI]) for the PDFF comparisons were 0.98 (0.96-0.99) for BH-, 0.99 (0.97-0.99) for BL-, and 0.99 (0.98-0.99) for NV-CSE. The statistical equivalence test revealed that the mean difference in PDFF and R2* between any two of the three CSE-MRI methods was less than ±1 percentage point (pp) and ±5 s(-1) , respectively (P < 0.046).CONCLUSION: Respiratory-gated CSE-MRI with respiratory bellows or navigator echo are feasible methods to quantify liver PDFF and R2* and are as valid as the standard breath-hold technique.

AB - PURPOSE: To evaluate free-breathing chemical shift-encoded (CSE) magnetic resonance imaging (MRI) for quantification of hepatic proton density fat-fraction (PDFF). A secondary purpose was to evaluate hepatic R2* values measured using free-breathing quantitative CSE-MRI.MATERIALS AND METHODS: Fifty patients (mean age, 56 years) were prospectively recruited and underwent the following four acquisitions to measure PDFF and R2*; 1) conventional breath-hold CSE-MRI (BH-CSE); 2) respiratory-gated CSE-MRI using respiratory bellows (BL-CSE); 3) respiratory-gated CSE-MRI using navigator echoes (NV-CSE); and 4) single voxel MR spectroscopy (MRS) as the reference standard for PDFF. Image quality was evaluated by two radiologists. MRI-PDFF measured from the three CSE-MRI methods were compared with MRS-PDFF using linear regression. The PDFF and R2* values were compared using two one-sided t-test to evaluate statistical equivalence.RESULTS: There was no significant difference in the image quality scores among the three CSE-MRI methods for either PDFF (P = 1.000) or R2* maps (P = 0.359-1.000). Correlation coefficients (95% confidence interval [CI]) for the PDFF comparisons were 0.98 (0.96-0.99) for BH-, 0.99 (0.97-0.99) for BL-, and 0.99 (0.98-0.99) for NV-CSE. The statistical equivalence test revealed that the mean difference in PDFF and R2* between any two of the three CSE-MRI methods was less than ±1 percentage point (pp) and ±5 s(-1) , respectively (P < 0.046).CONCLUSION: Respiratory-gated CSE-MRI with respiratory bellows or navigator echo are feasible methods to quantify liver PDFF and R2* and are as valid as the standard breath-hold technique.

KW - Fatty Liver

KW - Female

KW - Humans

KW - Liver

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Protons

KW - Reproducibility of Results

KW - Journal Article

U2 - 10.1002/jmri.24896

DO - 10.1002/jmri.24896

M3 - SCORING: Journal article

C2 - 25828696

VL - 42

SP - 1241

EP - 1248

JO - J MAGN RESON IMAGING

JF - J MAGN RESON IMAGING

SN - 1053-1807

IS - 5

ER -