Quantification of [18F]-FDG uptake in atherosclerotic plaque: impact of renal function
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Quantification of [18F]-FDG uptake in atherosclerotic plaque: impact of renal function. / Derlin, Thorsten; Habermann, Christian R; Hahne, Jasmin D; Apostolova, Ivayla; Klutmann, Susanne; Mester, Janos; Buchert, Ralph.
In: ANN NUCL MED, Vol. 25, No. 8, 10.2011, p. 586-91.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Quantification of [18F]-FDG uptake in atherosclerotic plaque: impact of renal function
AU - Derlin, Thorsten
AU - Habermann, Christian R
AU - Hahne, Jasmin D
AU - Apostolova, Ivayla
AU - Klutmann, Susanne
AU - Mester, Janos
AU - Buchert, Ralph
PY - 2011/10
Y1 - 2011/10
N2 - OBJECTIVE: Impaired renal function causes both increased and prolonged tracer availability in the blood-pool which might result in increased tracer accumulation in atherosclerotic lesions. Therefore, the aim of this study was to investigate a possible correlation between the intensity of tracer uptake in atherosclerotic lesions and renal function.METHODS: Data from 50 [18F]-FDG scans were visually evaluated for tracer uptake in vessel wall alterations. Lesions were analyzed semiquantitatively by determining the blood-pool standardized uptake values (SUV(blood-pool)s), maximum SUVs (SUV(max)s), and the target-to-background ratio (TBR). These parameters were tested for correlation with estimated glomerular filtration rate (eGFR), and cardiovascular risk factors.RESULTS: Both SUV(blood-pool)s (r(s) = -0.32, p = 0.03) and SUV(max)s for [18F]-FDG (r(s) = -0.50, p < 0.0001) showed a significant negative correlation with eGFR. TBRs for [18F]-FDG demonstrated a significant positive correlation with eGFRs (r(s) = 0.21, p = 0.02).CONCLUSION: This study found that both intravascular tracer availability (SUV(blood-pool)) and intralesional tracer uptake (SUV(max)) are influenced by renal function. Calculation of TBR to account for that effect may result in overcorrection in case of [(18)F]-FDG. Renal insufficiency or subclinical changes in renal function have to be considered as a confounding factor in PET of atherosclerotic lesions.
AB - OBJECTIVE: Impaired renal function causes both increased and prolonged tracer availability in the blood-pool which might result in increased tracer accumulation in atherosclerotic lesions. Therefore, the aim of this study was to investigate a possible correlation between the intensity of tracer uptake in atherosclerotic lesions and renal function.METHODS: Data from 50 [18F]-FDG scans were visually evaluated for tracer uptake in vessel wall alterations. Lesions were analyzed semiquantitatively by determining the blood-pool standardized uptake values (SUV(blood-pool)s), maximum SUVs (SUV(max)s), and the target-to-background ratio (TBR). These parameters were tested for correlation with estimated glomerular filtration rate (eGFR), and cardiovascular risk factors.RESULTS: Both SUV(blood-pool)s (r(s) = -0.32, p = 0.03) and SUV(max)s for [18F]-FDG (r(s) = -0.50, p < 0.0001) showed a significant negative correlation with eGFR. TBRs for [18F]-FDG demonstrated a significant positive correlation with eGFRs (r(s) = 0.21, p = 0.02).CONCLUSION: This study found that both intravascular tracer availability (SUV(blood-pool)) and intralesional tracer uptake (SUV(max)) are influenced by renal function. Calculation of TBR to account for that effect may result in overcorrection in case of [(18)F]-FDG. Renal insufficiency or subclinical changes in renal function have to be considered as a confounding factor in PET of atherosclerotic lesions.
KW - Adult
KW - Aged
KW - Atherosclerosis
KW - Female
KW - Fluorodeoxyglucose F18
KW - Glomerular Filtration Rate
KW - Humans
KW - Kidney
KW - Kidney Function Tests
KW - Male
KW - Middle Aged
KW - Plaque, Atherosclerotic
KW - Positron-Emission Tomography
KW - Risk Factors
KW - Tomography, X-Ray Computed
KW - Journal Article
U2 - 10.1007/s12149-011-0503-1
DO - 10.1007/s12149-011-0503-1
M3 - SCORING: Journal article
C2 - 21656104
VL - 25
SP - 586
EP - 591
JO - ANN NUCL MED
JF - ANN NUCL MED
SN - 0914-7187
IS - 8
ER -