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Quantification of [18F]-FDG uptake in atherosclerotic plaque: impact of renal function

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Quantification of [18F]-FDG uptake in atherosclerotic plaque: impact of renal function. / Derlin, Thorsten; Habermann, Christian R; Hahne, Jasmin D; Apostolova, Ivayla; Klutmann, Susanne; Mester, Janos; Buchert, Ralph.

in: ANN NUCL MED, Jahrgang 25, Nr. 8, 10.2011, S. 586-91.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Derlin, T, Habermann, CR, Hahne, JD, Apostolova, I, Klutmann, S, Mester, J & Buchert, R 2011, 'Quantification of [18F]-FDG uptake in atherosclerotic plaque: impact of renal function', ANN NUCL MED, Jg. 25, Nr. 8, S. 586-91. https://doi.org/10.1007/s12149-011-0503-1

APA

Derlin, T., Habermann, C. R., Hahne, J. D., Apostolova, I., Klutmann, S., Mester, J., & Buchert, R. (2011). Quantification of [18F]-FDG uptake in atherosclerotic plaque: impact of renal function. ANN NUCL MED, 25(8), 586-91. https://doi.org/10.1007/s12149-011-0503-1

Vancouver

Derlin T, Habermann CR, Hahne JD, Apostolova I, Klutmann S, Mester J et al. Quantification of [18F]-FDG uptake in atherosclerotic plaque: impact of renal function. ANN NUCL MED. 2011 Okt;25(8):586-91. https://doi.org/10.1007/s12149-011-0503-1

Bibtex

@article{46d726d827ae40c4a71dd63c9617270f,
title = "Quantification of [18F]-FDG uptake in atherosclerotic plaque: impact of renal function",
abstract = "OBJECTIVE: Impaired renal function causes both increased and prolonged tracer availability in the blood-pool which might result in increased tracer accumulation in atherosclerotic lesions. Therefore, the aim of this study was to investigate a possible correlation between the intensity of tracer uptake in atherosclerotic lesions and renal function.METHODS: Data from 50 [18F]-FDG scans were visually evaluated for tracer uptake in vessel wall alterations. Lesions were analyzed semiquantitatively by determining the blood-pool standardized uptake values (SUV(blood-pool)s), maximum SUVs (SUV(max)s), and the target-to-background ratio (TBR). These parameters were tested for correlation with estimated glomerular filtration rate (eGFR), and cardiovascular risk factors.RESULTS: Both SUV(blood-pool)s (r(s) = -0.32, p = 0.03) and SUV(max)s for [18F]-FDG (r(s) = -0.50, p < 0.0001) showed a significant negative correlation with eGFR. TBRs for [18F]-FDG demonstrated a significant positive correlation with eGFRs (r(s) = 0.21, p = 0.02).CONCLUSION: This study found that both intravascular tracer availability (SUV(blood-pool)) and intralesional tracer uptake (SUV(max)) are influenced by renal function. Calculation of TBR to account for that effect may result in overcorrection in case of [(18)F]-FDG. Renal insufficiency or subclinical changes in renal function have to be considered as a confounding factor in PET of atherosclerotic lesions.",
keywords = "Adult, Aged, Atherosclerosis, Female, Fluorodeoxyglucose F18, Glomerular Filtration Rate, Humans, Kidney, Kidney Function Tests, Male, Middle Aged, Plaque, Atherosclerotic, Positron-Emission Tomography, Risk Factors, Tomography, X-Ray Computed, Journal Article",
author = "Thorsten Derlin and Habermann, {Christian R} and Hahne, {Jasmin D} and Ivayla Apostolova and Susanne Klutmann and Janos Mester and Ralph Buchert",
year = "2011",
month = oct,
doi = "10.1007/s12149-011-0503-1",
language = "English",
volume = "25",
pages = "586--91",
journal = "ANN NUCL MED",
issn = "0914-7187",
publisher = "Springer Japan",
number = "8",

}

RIS

TY - JOUR

T1 - Quantification of [18F]-FDG uptake in atherosclerotic plaque: impact of renal function

AU - Derlin, Thorsten

AU - Habermann, Christian R

AU - Hahne, Jasmin D

AU - Apostolova, Ivayla

AU - Klutmann, Susanne

AU - Mester, Janos

AU - Buchert, Ralph

PY - 2011/10

Y1 - 2011/10

N2 - OBJECTIVE: Impaired renal function causes both increased and prolonged tracer availability in the blood-pool which might result in increased tracer accumulation in atherosclerotic lesions. Therefore, the aim of this study was to investigate a possible correlation between the intensity of tracer uptake in atherosclerotic lesions and renal function.METHODS: Data from 50 [18F]-FDG scans were visually evaluated for tracer uptake in vessel wall alterations. Lesions were analyzed semiquantitatively by determining the blood-pool standardized uptake values (SUV(blood-pool)s), maximum SUVs (SUV(max)s), and the target-to-background ratio (TBR). These parameters were tested for correlation with estimated glomerular filtration rate (eGFR), and cardiovascular risk factors.RESULTS: Both SUV(blood-pool)s (r(s) = -0.32, p = 0.03) and SUV(max)s for [18F]-FDG (r(s) = -0.50, p < 0.0001) showed a significant negative correlation with eGFR. TBRs for [18F]-FDG demonstrated a significant positive correlation with eGFRs (r(s) = 0.21, p = 0.02).CONCLUSION: This study found that both intravascular tracer availability (SUV(blood-pool)) and intralesional tracer uptake (SUV(max)) are influenced by renal function. Calculation of TBR to account for that effect may result in overcorrection in case of [(18)F]-FDG. Renal insufficiency or subclinical changes in renal function have to be considered as a confounding factor in PET of atherosclerotic lesions.

AB - OBJECTIVE: Impaired renal function causes both increased and prolonged tracer availability in the blood-pool which might result in increased tracer accumulation in atherosclerotic lesions. Therefore, the aim of this study was to investigate a possible correlation between the intensity of tracer uptake in atherosclerotic lesions and renal function.METHODS: Data from 50 [18F]-FDG scans were visually evaluated for tracer uptake in vessel wall alterations. Lesions were analyzed semiquantitatively by determining the blood-pool standardized uptake values (SUV(blood-pool)s), maximum SUVs (SUV(max)s), and the target-to-background ratio (TBR). These parameters were tested for correlation with estimated glomerular filtration rate (eGFR), and cardiovascular risk factors.RESULTS: Both SUV(blood-pool)s (r(s) = -0.32, p = 0.03) and SUV(max)s for [18F]-FDG (r(s) = -0.50, p < 0.0001) showed a significant negative correlation with eGFR. TBRs for [18F]-FDG demonstrated a significant positive correlation with eGFRs (r(s) = 0.21, p = 0.02).CONCLUSION: This study found that both intravascular tracer availability (SUV(blood-pool)) and intralesional tracer uptake (SUV(max)) are influenced by renal function. Calculation of TBR to account for that effect may result in overcorrection in case of [(18)F]-FDG. Renal insufficiency or subclinical changes in renal function have to be considered as a confounding factor in PET of atherosclerotic lesions.

KW - Adult

KW - Aged

KW - Atherosclerosis

KW - Female

KW - Fluorodeoxyglucose F18

KW - Glomerular Filtration Rate

KW - Humans

KW - Kidney

KW - Kidney Function Tests

KW - Male

KW - Middle Aged

KW - Plaque, Atherosclerotic

KW - Positron-Emission Tomography

KW - Risk Factors

KW - Tomography, X-Ray Computed

KW - Journal Article

U2 - 10.1007/s12149-011-0503-1

DO - 10.1007/s12149-011-0503-1

M3 - SCORING: Journal article

C2 - 21656104

VL - 25

SP - 586

EP - 591

JO - ANN NUCL MED

JF - ANN NUCL MED

SN - 0914-7187

IS - 8

ER -