Protein intake in infancy and carotid intima media thickness at 5 years--a secondary analysis from a randomized trial
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Protein intake in infancy and carotid intima media thickness at 5 years--a secondary analysis from a randomized trial. / Gruszfeld, Dariusz; Weber, Martina; Nowakowska-Rysz, Monika; Janas, Roman; Kozlik-Feldmann, Rainer; Xhonneux, Annick; Carlier, Clotilde; Riva, Enrica; Verduci, Elvira; Closa-Monasterolo, Ricardo; Escribano, Joaquin; Dobrzanska, Anna; Koletzko, Berthold; European Childhood Obesity Study Group.
In: ANN NUTR METAB, Vol. 66, No. 1, 2015, p. 51-59.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Protein intake in infancy and carotid intima media thickness at 5 years--a secondary analysis from a randomized trial
AU - Gruszfeld, Dariusz
AU - Weber, Martina
AU - Nowakowska-Rysz, Monika
AU - Janas, Roman
AU - Kozlik-Feldmann, Rainer
AU - Xhonneux, Annick
AU - Carlier, Clotilde
AU - Riva, Enrica
AU - Verduci, Elvira
AU - Closa-Monasterolo, Ricardo
AU - Escribano, Joaquin
AU - Dobrzanska, Anna
AU - Koletzko, Berthold
AU - European Childhood Obesity Study Group
N1 - © 2015 S. Karger AG, Basel.
PY - 2015
Y1 - 2015
N2 - BACKGROUND: Nutrition in childhood has an influence on the cardiovascular function later on in life. European Childhood Obesity Project is a multicenter, randomized clinical intervention trial examining the effect of early protein intake on later health outcomes, particularly adiposity and related disorders. The aim of the study was to examine the effect of nutritional intervention--different protein intake in infancy on carotid intima-media thickness (cIMT) at 5 years. The association of cardiovascular risk factors with cIMT was also assessed.METHODS: Healthy term formula-fed infants in five European countries were enrolled either to the higher (HP) or to the lower (LP) protein group. Observational group consisted of breastfed infants. Plasma insulin, glucose, lipid profile, IGF-1, apolipoprotein A1 and B were measured as well as anthropometric parameters of parents and a child, blood pressure and physical activity.RESULTS: No difference in cIMT between HP and LP group was observed. Insulin, HOMA-IR index and total IGF-1 were positively associated with cIMT but after adjustment for confounders only an inverse association between ApoA1 and positive between ApoB/ApoA1 and cIMT were significant.CONCLUSION: High versus low protein intake in infancy does not influence cIMT at 5 years. cIMT in healthy children at 5 years is associated with their apolipoprotein profile.
AB - BACKGROUND: Nutrition in childhood has an influence on the cardiovascular function later on in life. European Childhood Obesity Project is a multicenter, randomized clinical intervention trial examining the effect of early protein intake on later health outcomes, particularly adiposity and related disorders. The aim of the study was to examine the effect of nutritional intervention--different protein intake in infancy on carotid intima-media thickness (cIMT) at 5 years. The association of cardiovascular risk factors with cIMT was also assessed.METHODS: Healthy term formula-fed infants in five European countries were enrolled either to the higher (HP) or to the lower (LP) protein group. Observational group consisted of breastfed infants. Plasma insulin, glucose, lipid profile, IGF-1, apolipoprotein A1 and B were measured as well as anthropometric parameters of parents and a child, blood pressure and physical activity.RESULTS: No difference in cIMT between HP and LP group was observed. Insulin, HOMA-IR index and total IGF-1 were positively associated with cIMT but after adjustment for confounders only an inverse association between ApoA1 and positive between ApoB/ApoA1 and cIMT were significant.CONCLUSION: High versus low protein intake in infancy does not influence cIMT at 5 years. cIMT in healthy children at 5 years is associated with their apolipoprotein profile.
KW - Apolipoprotein A-I/blood
KW - Apolipoprotein B-100/blood
KW - Blood Glucose
KW - Blood Pressure
KW - Body Mass Index
KW - Breast Feeding
KW - Cardiovascular Diseases/pathology
KW - Carotid Intima-Media Thickness/statistics & numerical data
KW - Child, Preschool
KW - Dietary Proteins/administration & dosage
KW - Europe
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Infant
KW - Infant Formula/administration & dosage
KW - Infant Nutritional Physiological Phenomena
KW - Infant, Newborn
KW - Insulin/blood
KW - Insulin-Like Growth Factor I/analysis
KW - Lipids/blood
KW - Male
KW - Motor Activity
KW - Risk Factors
U2 - 10.1159/000369980
DO - 10.1159/000369980
M3 - SCORING: Journal article
C2 - 25572773
VL - 66
SP - 51
EP - 59
JO - ANN NUTR METAB
JF - ANN NUTR METAB
SN - 0250-6807
IS - 1
ER -