Prostate volume and adverse prostate cancer features: fact not artifact.
Standard
Prostate volume and adverse prostate cancer features: fact not artifact. / Briganti, Alberto; Chun, Felix; Suardi, Nazareno; Gallina, Andrea; Walz, Jochen; Graefen, Markus; Shariat, Shahrokh; Ebersdobler, Andreas; Rigatti, Patrizio; Perrotte, Paul; Saad, Fred; Montorsi, Francesco; Huland, Hartwig; Karakiewicz, Pierre I.
In: EUR J CANCER, Vol. 43, No. 18, 18, 2007, p. 2669-2677.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Prostate volume and adverse prostate cancer features: fact not artifact.
AU - Briganti, Alberto
AU - Chun, Felix
AU - Suardi, Nazareno
AU - Gallina, Andrea
AU - Walz, Jochen
AU - Graefen, Markus
AU - Shariat, Shahrokh
AU - Ebersdobler, Andreas
AU - Rigatti, Patrizio
AU - Perrotte, Paul
AU - Saad, Fred
AU - Montorsi, Francesco
AU - Huland, Hartwig
AU - Karakiewicz, Pierre I
PY - 2007
Y1 - 2007
N2 - PURPOSE: A recent prostate cancer finasteride chemoprevention trial showed a higher rate of sextant biopsy-detected high grade prostate cancer (HGPCa) in finasteride exposed men, whose prostates were significantly smaller than those of controls. We investigated the association between prostate size and prostate cancer grade and stage in a large (n=3412) single center radical prostatectomy cohort, which was unexposed to any form of hormonal manipulation. METHODS: Logistic regression models were used. RESULTS: Small prostates were associated with higher rate of HGPCa at biopsy and at radical prostatectomy (both p3.4 cc, after accounting for age, PSA, clinical stage and year of surgery. CONCLUSIONS: Our findings demonstrate that prostate cancers located in small glands are fundamentally more aggressive than those located within larger glands. In consequence, prostate cancer detection and treatment strategies should account for prostate volume.
AB - PURPOSE: A recent prostate cancer finasteride chemoprevention trial showed a higher rate of sextant biopsy-detected high grade prostate cancer (HGPCa) in finasteride exposed men, whose prostates were significantly smaller than those of controls. We investigated the association between prostate size and prostate cancer grade and stage in a large (n=3412) single center radical prostatectomy cohort, which was unexposed to any form of hormonal manipulation. METHODS: Logistic regression models were used. RESULTS: Small prostates were associated with higher rate of HGPCa at biopsy and at radical prostatectomy (both p3.4 cc, after accounting for age, PSA, clinical stage and year of surgery. CONCLUSIONS: Our findings demonstrate that prostate cancers located in small glands are fundamentally more aggressive than those located within larger glands. In consequence, prostate cancer detection and treatment strategies should account for prostate volume.
M3 - SCORING: Zeitschriftenaufsatz
VL - 43
SP - 2669
EP - 2677
JO - EUR J CANCER
JF - EUR J CANCER
SN - 0959-8049
IS - 18
M1 - 18
ER -