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Prostate volume and adverse prostate cancer features: fact not artifact.

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Prostate volume and adverse prostate cancer features: fact not artifact. / Briganti, Alberto; Chun, Felix; Suardi, Nazareno; Gallina, Andrea; Walz, Jochen; Graefen, Markus; Shariat, Shahrokh; Ebersdobler, Andreas; Rigatti, Patrizio; Perrotte, Paul; Saad, Fred; Montorsi, Francesco; Huland, Hartwig; Karakiewicz, Pierre I.

in: EUR J CANCER, Jahrgang 43, Nr. 18, 18, 2007, S. 2669-2677.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Briganti, A, Chun, F, Suardi, N, Gallina, A, Walz, J, Graefen, M, Shariat, S, Ebersdobler, A, Rigatti, P, Perrotte, P, Saad, F, Montorsi, F, Huland, H & Karakiewicz, PI 2007, 'Prostate volume and adverse prostate cancer features: fact not artifact.', EUR J CANCER, Jg. 43, Nr. 18, 18, S. 2669-2677. <http://www.ncbi.nlm.nih.gov/pubmed/17996442?dopt=Citation>

APA

Briganti, A., Chun, F., Suardi, N., Gallina, A., Walz, J., Graefen, M., Shariat, S., Ebersdobler, A., Rigatti, P., Perrotte, P., Saad, F., Montorsi, F., Huland, H., & Karakiewicz, P. I. (2007). Prostate volume and adverse prostate cancer features: fact not artifact. EUR J CANCER, 43(18), 2669-2677. [18]. http://www.ncbi.nlm.nih.gov/pubmed/17996442?dopt=Citation

Vancouver

Briganti A, Chun F, Suardi N, Gallina A, Walz J, Graefen M et al. Prostate volume and adverse prostate cancer features: fact not artifact. EUR J CANCER. 2007;43(18):2669-2677. 18.

Bibtex

@article{273c0f5a48e343acb2cf6c626b897232,
title = "Prostate volume and adverse prostate cancer features: fact not artifact.",
abstract = "PURPOSE: A recent prostate cancer finasteride chemoprevention trial showed a higher rate of sextant biopsy-detected high grade prostate cancer (HGPCa) in finasteride exposed men, whose prostates were significantly smaller than those of controls. We investigated the association between prostate size and prostate cancer grade and stage in a large (n=3412) single center radical prostatectomy cohort, which was unexposed to any form of hormonal manipulation. METHODS: Logistic regression models were used. RESULTS: Small prostates were associated with higher rate of HGPCa at biopsy and at radical prostatectomy (both p3.4 cc, after accounting for age, PSA, clinical stage and year of surgery. CONCLUSIONS: Our findings demonstrate that prostate cancers located in small glands are fundamentally more aggressive than those located within larger glands. In consequence, prostate cancer detection and treatment strategies should account for prostate volume.",
author = "Alberto Briganti and Felix Chun and Nazareno Suardi and Andrea Gallina and Jochen Walz and Markus Graefen and Shahrokh Shariat and Andreas Ebersdobler and Patrizio Rigatti and Paul Perrotte and Fred Saad and Francesco Montorsi and Hartwig Huland and Karakiewicz, {Pierre I}",
year = "2007",
language = "Deutsch",
volume = "43",
pages = "2669--2677",
journal = "EUR J CANCER",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "18",

}

RIS

TY - JOUR

T1 - Prostate volume and adverse prostate cancer features: fact not artifact.

AU - Briganti, Alberto

AU - Chun, Felix

AU - Suardi, Nazareno

AU - Gallina, Andrea

AU - Walz, Jochen

AU - Graefen, Markus

AU - Shariat, Shahrokh

AU - Ebersdobler, Andreas

AU - Rigatti, Patrizio

AU - Perrotte, Paul

AU - Saad, Fred

AU - Montorsi, Francesco

AU - Huland, Hartwig

AU - Karakiewicz, Pierre I

PY - 2007

Y1 - 2007

N2 - PURPOSE: A recent prostate cancer finasteride chemoprevention trial showed a higher rate of sextant biopsy-detected high grade prostate cancer (HGPCa) in finasteride exposed men, whose prostates were significantly smaller than those of controls. We investigated the association between prostate size and prostate cancer grade and stage in a large (n=3412) single center radical prostatectomy cohort, which was unexposed to any form of hormonal manipulation. METHODS: Logistic regression models were used. RESULTS: Small prostates were associated with higher rate of HGPCa at biopsy and at radical prostatectomy (both p3.4 cc, after accounting for age, PSA, clinical stage and year of surgery. CONCLUSIONS: Our findings demonstrate that prostate cancers located in small glands are fundamentally more aggressive than those located within larger glands. In consequence, prostate cancer detection and treatment strategies should account for prostate volume.

AB - PURPOSE: A recent prostate cancer finasteride chemoprevention trial showed a higher rate of sextant biopsy-detected high grade prostate cancer (HGPCa) in finasteride exposed men, whose prostates were significantly smaller than those of controls. We investigated the association between prostate size and prostate cancer grade and stage in a large (n=3412) single center radical prostatectomy cohort, which was unexposed to any form of hormonal manipulation. METHODS: Logistic regression models were used. RESULTS: Small prostates were associated with higher rate of HGPCa at biopsy and at radical prostatectomy (both p3.4 cc, after accounting for age, PSA, clinical stage and year of surgery. CONCLUSIONS: Our findings demonstrate that prostate cancers located in small glands are fundamentally more aggressive than those located within larger glands. In consequence, prostate cancer detection and treatment strategies should account for prostate volume.

M3 - SCORING: Zeitschriftenaufsatz

VL - 43

SP - 2669

EP - 2677

JO - EUR J CANCER

JF - EUR J CANCER

SN - 0959-8049

IS - 18

M1 - 18

ER -