Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly
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Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly. / Fischer, Karina; Melo van Lent, Debora; Wolfsgruber, Steffen; Weinhold, Leonie; Kleineidam, Luca; Bickel, Horst; Scherer, Martin; Eisele, Marion; van den Bussche, Hendrik; Wiese, Birgitt; König, Hans-Helmut; Weyerer, Siegfried; Pentzek, Michael; Röhr, Susanne; Maier, Wolfgang; Jessen, Frank; Schmid, Matthias; Riedel-Heller, Steffi G; Wagner, Michael.
In: NUTRIENTS, Vol. 10, No. 7, 29.06.2018, p. 852.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly
AU - Fischer, Karina
AU - Melo van Lent, Debora
AU - Wolfsgruber, Steffen
AU - Weinhold, Leonie
AU - Kleineidam, Luca
AU - Bickel, Horst
AU - Scherer, Martin
AU - Eisele, Marion
AU - van den Bussche, Hendrik
AU - Wiese, Birgitt
AU - König, Hans-Helmut
AU - Weyerer, Siegfried
AU - Pentzek, Michael
AU - Röhr, Susanne
AU - Maier, Wolfgang
AU - Jessen, Frank
AU - Schmid, Matthias
AU - Riedel-Heller, Steffi G
AU - Wagner, Michael
PY - 2018/6/29
Y1 - 2018/6/29
N2 - Background: Evidence whether single “cognitive health” foods could prevent cognitive decline is limited. We investigated whether dietary intake of red wine, white wine, coffee, green tea, olive oil, fresh fish, fruits and vegetables, red meat and sausages, assessed by a single-food-questionnaire, would be associated with either incident Alzheimer’s dementia (AD) or verbal memory decline. Methods: Participants aged 75+ of the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) cohort were regularly followed over 10 years (n = 2622; n = 418 incident AD cases). Multivariable-adjusted joint modeling of repeated-measures and survival analysis was used, taking gender and Apolipoprotein E4 (APOE ε4) genotype into account as possible effect modifiers. Results: Only higher red wine intake was associated with a lower incidence of AD (HR = 0.92; P = 0.045). Interestingly, this was true only for men (HR = 0.82; P < 0.001), while in women higher red wine intake was associated with a higher incidence of AD (HR = 1.15; P = 0.044), and higher white wine intake with a more pronounced memory decline over time (HR = −0.13; P = 0.052). Conclusion: We found no evidence for these single foods to be protective against cognitive decline, with the exception of red wine, which reduced the risk for AD only in men. Women could be more susceptible to detrimental effects of alcohol.
AB - Background: Evidence whether single “cognitive health” foods could prevent cognitive decline is limited. We investigated whether dietary intake of red wine, white wine, coffee, green tea, olive oil, fresh fish, fruits and vegetables, red meat and sausages, assessed by a single-food-questionnaire, would be associated with either incident Alzheimer’s dementia (AD) or verbal memory decline. Methods: Participants aged 75+ of the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) cohort were regularly followed over 10 years (n = 2622; n = 418 incident AD cases). Multivariable-adjusted joint modeling of repeated-measures and survival analysis was used, taking gender and Apolipoprotein E4 (APOE ε4) genotype into account as possible effect modifiers. Results: Only higher red wine intake was associated with a lower incidence of AD (HR = 0.92; P = 0.045). Interestingly, this was true only for men (HR = 0.82; P < 0.001), while in women higher red wine intake was associated with a higher incidence of AD (HR = 1.15; P = 0.044), and higher white wine intake with a more pronounced memory decline over time (HR = −0.13; P = 0.052). Conclusion: We found no evidence for these single foods to be protective against cognitive decline, with the exception of red wine, which reduced the risk for AD only in men. Women could be more susceptible to detrimental effects of alcohol.
KW - Journal Article
U2 - 10.3390/nu10070852
DO - 10.3390/nu10070852
M3 - SCORING: Journal article
C2 - 29966314
VL - 10
SP - 852
JO - NUTRIENTS
JF - NUTRIENTS
SN - 2072-6643
IS - 7
ER -