Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly

TY - JOUR

T1 - Prospective Associations between Single Foods, Alzheimer's Dementia and Memory Decline in the Elderly

AU - Fischer, Karina

AU - Melo van Lent, Debora

AU - Wolfsgruber, Steffen

AU - Weinhold, Leonie

AU - Kleineidam, Luca

AU - Bickel, Horst

AU - Scherer, Martin

AU - Eisele, Marion

AU - van den Bussche, Hendrik

AU - Wiese, Birgitt

AU - König, Hans-Helmut

AU - Weyerer, Siegfried

AU - Pentzek, Michael

AU - Röhr, Susanne

AU - Maier, Wolfgang

AU - Jessen, Frank

AU - Schmid, Matthias

AU - Riedel-Heller, Steffi G

AU - Wagner, Michael

PY - 2018/6/29

Y1 - 2018/6/29

N2 - Background: Evidence whether single &ldquo;cognitive health&rdquo; foods could prevent cognitive decline is limited. We investigated whether dietary intake of red wine, white wine, coffee, green tea, olive oil, fresh fish, fruits and vegetables, red meat and sausages, assessed by a single-food-questionnaire, would be associated with either incident Alzheimer&rsquo;s dementia (AD) or verbal memory decline. Methods: Participants aged 75+ of the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) cohort were regularly followed over 10 years (n = 2622; n = 418 incident AD cases). Multivariable-adjusted joint modeling of repeated-measures and survival analysis was used, taking gender and Apolipoprotein E4 (APOE &epsilon;4) genotype into account as possible effect modifiers. Results: Only higher red wine intake was associated with a lower incidence of AD (HR = 0.92; P = 0.045). Interestingly, this was true only for men (HR = 0.82; P < 0.001), while in women higher red wine intake was associated with a higher incidence of AD (HR = 1.15; P = 0.044), and higher white wine intake with a more pronounced memory decline over time (HR = &minus;0.13; P = 0.052). Conclusion: We found no evidence for these single foods to be protective against cognitive decline, with the exception of red wine, which reduced the risk for AD only in men. Women could be more susceptible to detrimental effects of alcohol.

AB - Background: Evidence whether single &ldquo;cognitive health&rdquo; foods could prevent cognitive decline is limited. We investigated whether dietary intake of red wine, white wine, coffee, green tea, olive oil, fresh fish, fruits and vegetables, red meat and sausages, assessed by a single-food-questionnaire, would be associated with either incident Alzheimer&rsquo;s dementia (AD) or verbal memory decline. Methods: Participants aged 75+ of the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) cohort were regularly followed over 10 years (n = 2622; n = 418 incident AD cases). Multivariable-adjusted joint modeling of repeated-measures and survival analysis was used, taking gender and Apolipoprotein E4 (APOE &epsilon;4) genotype into account as possible effect modifiers. Results: Only higher red wine intake was associated with a lower incidence of AD (HR = 0.92; P = 0.045). Interestingly, this was true only for men (HR = 0.82; P < 0.001), while in women higher red wine intake was associated with a higher incidence of AD (HR = 1.15; P = 0.044), and higher white wine intake with a more pronounced memory decline over time (HR = &minus;0.13; P = 0.052). Conclusion: We found no evidence for these single foods to be protective against cognitive decline, with the exception of red wine, which reduced the risk for AD only in men. Women could be more susceptible to detrimental effects of alcohol.

KW - Journal Article

U2 - 10.3390/nu10070852

DO - 10.3390/nu10070852

M3 - SCORING: Journal article

C2 - 29966314

VL - 10

SP - 852

JO - NUTRIENTS

JF - NUTRIENTS

SN - 2072-6643

IS - 7

ER -