Prolonged suppression of humoral immune response after organ transplantation
Standard
Prolonged suppression of humoral immune response after organ transplantation. / Gu, Y L; Dahmen, U; Dirsch, O; Polywka, S; Broelsch, C E.
In: EUR SURG RES, Vol. 34, No. 3, 22.06.2002, p. 260-5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Prolonged suppression of humoral immune response after organ transplantation
AU - Gu, Y L
AU - Dahmen, U
AU - Dirsch, O
AU - Polywka, S
AU - Broelsch, C E
N1 - Copyright 2002 S. Karger AG, Basel
PY - 2002/6/22
Y1 - 2002/6/22
N2 - Rats receiving either kidney or liver grafts were vaccinated with recombinant hepatitis B virus (HBV) vaccine either 1 or 10 weeks post-transplantation to explore the nonspecific immunosuppressive effect of transplantation surgery on antibody development. Response rate and geometric mean titer of the anti-HBs antibody were significantly lower in organ-transplanted animals undergoing early vaccination compared to unoperated control animals. Both parameters were affected when vaccination was performed early after kidney transplantation, but also in case of late vaccination in liver graft recipients. The nonspecific suppressive effect of transplantation surgery on the humoral immune response was related to the time point of vaccination after surgery and the extent of the surgical intervention and lasted longer than previously reported.
AB - Rats receiving either kidney or liver grafts were vaccinated with recombinant hepatitis B virus (HBV) vaccine either 1 or 10 weeks post-transplantation to explore the nonspecific immunosuppressive effect of transplantation surgery on antibody development. Response rate and geometric mean titer of the anti-HBs antibody were significantly lower in organ-transplanted animals undergoing early vaccination compared to unoperated control animals. Both parameters were affected when vaccination was performed early after kidney transplantation, but also in case of late vaccination in liver graft recipients. The nonspecific suppressive effect of transplantation surgery on the humoral immune response was related to the time point of vaccination after surgery and the extent of the surgical intervention and lasted longer than previously reported.
KW - Animals
KW - Antibody Formation
KW - Hepatitis B Antibodies
KW - Hepatitis B Vaccines
KW - Immune Tolerance
KW - Kidney Transplantation
KW - Liver Transplantation
KW - Male
KW - Rats
KW - Rats, Inbred Lew
KW - Time Factors
KW - Transplantation Immunology
KW - Vaccination
KW - Vaccines, Synthetic
KW - Journal Article
U2 - 10.1159/000063398
DO - 10.1159/000063398
M3 - SCORING: Journal article
C2 - 12077514
VL - 34
SP - 260
EP - 265
JO - EUR SURG RES
JF - EUR SURG RES
SN - 0014-312X
IS - 3
ER -