Prolonged suppression of humoral immune response after organ transplantation

Y L Gu; U Dahmen; O Dirsch; S Polywka; C E Broelsch

doi:10.1159/000063398

Prolonged suppression of humoral immune response after organ transplantation

Standard

Prolonged suppression of humoral immune response after organ transplantation. / Gu, Y L; Dahmen, U; Dirsch, O; Polywka, S; Broelsch, C E.

in: EUR SURG RES, Jahrgang 34, Nr. 3, 22.06.2002, S. 260-5.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gu, YL, Dahmen, U, Dirsch, O, Polywka, S & Broelsch, CE 2002, 'Prolonged suppression of humoral immune response after organ transplantation', EUR SURG RES, Jg. 34, Nr. 3, S. 260-5. https://doi.org/10.1159/000063398

APA

Gu, Y. L., Dahmen, U., Dirsch, O., Polywka, S., & Broelsch, C. E. (2002). Prolonged suppression of humoral immune response after organ transplantation. EUR SURG RES, 34(3), 260-5. https://doi.org/10.1159/000063398

Vancouver

Gu YL, Dahmen U, Dirsch O, Polywka S, Broelsch CE. Prolonged suppression of humoral immune response after organ transplantation. EUR SURG RES. 2002 Jun 22;34(3):260-5. https://doi.org/10.1159/000063398

Bibtex

@article{bf454e57611f45e484260751198e2f1f,

title = "Prolonged suppression of humoral immune response after organ transplantation",

abstract = "Rats receiving either kidney or liver grafts were vaccinated with recombinant hepatitis B virus (HBV) vaccine either 1 or 10 weeks post-transplantation to explore the nonspecific immunosuppressive effect of transplantation surgery on antibody development. Response rate and geometric mean titer of the anti-HBs antibody were significantly lower in organ-transplanted animals undergoing early vaccination compared to unoperated control animals. Both parameters were affected when vaccination was performed early after kidney transplantation, but also in case of late vaccination in liver graft recipients. The nonspecific suppressive effect of transplantation surgery on the humoral immune response was related to the time point of vaccination after surgery and the extent of the surgical intervention and lasted longer than previously reported.",

keywords = "Animals, Antibody Formation, Hepatitis B Antibodies, Hepatitis B Vaccines, Immune Tolerance, Kidney Transplantation, Liver Transplantation, Male, Rats, Rats, Inbred Lew, Time Factors, Transplantation Immunology, Vaccination, Vaccines, Synthetic, Journal Article",

author = "Gu, {Y L} and U Dahmen and O Dirsch and S Polywka and Broelsch, {C E}",

year = "2002",

month = jun,

day = "22",

doi = "10.1159/000063398",

language = "English",

volume = "34",

pages = "260--5",

journal = "EUR SURG RES",

issn = "0014-312X",

publisher = "S. Karger AG",

number = "3",

}

RIS

TY - JOUR

T1 - Prolonged suppression of humoral immune response after organ transplantation

AU - Gu, Y L

AU - Dahmen, U

AU - Dirsch, O

AU - Polywka, S

AU - Broelsch, C E

PY - 2002/6/22

Y1 - 2002/6/22

N2 - Rats receiving either kidney or liver grafts were vaccinated with recombinant hepatitis B virus (HBV) vaccine either 1 or 10 weeks post-transplantation to explore the nonspecific immunosuppressive effect of transplantation surgery on antibody development. Response rate and geometric mean titer of the anti-HBs antibody were significantly lower in organ-transplanted animals undergoing early vaccination compared to unoperated control animals. Both parameters were affected when vaccination was performed early after kidney transplantation, but also in case of late vaccination in liver graft recipients. The nonspecific suppressive effect of transplantation surgery on the humoral immune response was related to the time point of vaccination after surgery and the extent of the surgical intervention and lasted longer than previously reported.

AB - Rats receiving either kidney or liver grafts were vaccinated with recombinant hepatitis B virus (HBV) vaccine either 1 or 10 weeks post-transplantation to explore the nonspecific immunosuppressive effect of transplantation surgery on antibody development. Response rate and geometric mean titer of the anti-HBs antibody were significantly lower in organ-transplanted animals undergoing early vaccination compared to unoperated control animals. Both parameters were affected when vaccination was performed early after kidney transplantation, but also in case of late vaccination in liver graft recipients. The nonspecific suppressive effect of transplantation surgery on the humoral immune response was related to the time point of vaccination after surgery and the extent of the surgical intervention and lasted longer than previously reported.

KW - Animals

KW - Antibody Formation

KW - Hepatitis B Antibodies

KW - Hepatitis B Vaccines

KW - Immune Tolerance

KW - Kidney Transplantation

KW - Liver Transplantation

KW - Male

KW - Rats

KW - Rats, Inbred Lew

KW - Time Factors

KW - Transplantation Immunology

KW - Vaccination

KW - Vaccines, Synthetic

KW - Journal Article

U2 - 10.1159/000063398

DO - 10.1159/000063398

M3 - SCORING: Journal article

C2 - 12077514

VL - 34

SP - 260

EP - 265

JO - EUR SURG RES

JF - EUR SURG RES

SN - 0014-312X

IS - 3

ER -