Primary sclerosing cholangitis and cholangiocarcinoma: pathogenesis and modes of diagnostics
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Primary sclerosing cholangitis and cholangiocarcinoma: pathogenesis and modes of diagnostics. / Ehlken, Hanno; Schramm, Christoph.
In: DIGEST DIS, Vol. 31, No. 1, 01.01.2013, p. 118-25.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Primary sclerosing cholangitis and cholangiocarcinoma: pathogenesis and modes of diagnostics
AU - Ehlken, Hanno
AU - Schramm, Christoph
N1 - Copyright © 2013 S. Karger AG, Basel.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease caused by progressive inflammation of the intra- and extrahepatic bile duct system. PSC patients have an increased risk to develop hepatobiliary as well as extrahepatic malignancies. The goal of a surveillance strategy for hepatobiliary malignancy in these patients is the detection of early cancer which will allow a potentially curative therapy. Here, we focus on a conceptual review of the pathogenesis of cholangiocellular carcinoma and gallbladder cancer and we will discuss a rational approach for the surveillance of these malignancies in PSC patients.
AB - Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease caused by progressive inflammation of the intra- and extrahepatic bile duct system. PSC patients have an increased risk to develop hepatobiliary as well as extrahepatic malignancies. The goal of a surveillance strategy for hepatobiliary malignancy in these patients is the detection of early cancer which will allow a potentially curative therapy. Here, we focus on a conceptual review of the pathogenesis of cholangiocellular carcinoma and gallbladder cancer and we will discuss a rational approach for the surveillance of these malignancies in PSC patients.
KW - Bile Duct Neoplasms
KW - Bile Ducts, Intrahepatic
KW - Cholangiocarcinoma
KW - Cholangitis, Sclerosing
KW - Diagnostic Techniques, Digestive System
KW - Gallbladder Neoplasms
KW - Humans
U2 - 10.1159/000347206
DO - 10.1159/000347206
M3 - SCORING: Journal article
C2 - 23797133
VL - 31
SP - 118
EP - 125
JO - DIGEST DIS
JF - DIGEST DIS
SN - 0257-2753
IS - 1
ER -