Primary sclerosing cholangitis and cholangiocarcinoma: pathogenesis and modes of diagnostics

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Primary sclerosing cholangitis and cholangiocarcinoma: pathogenesis and modes of diagnostics. / Ehlken, Hanno; Schramm, Christoph.

in: DIGEST DIS, Jahrgang 31, Nr. 1, 01.01.2013, S. 118-25.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{70303a41bafa4481844af1cea11cbca8,
title = "Primary sclerosing cholangitis and cholangiocarcinoma: pathogenesis and modes of diagnostics",
abstract = "Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease caused by progressive inflammation of the intra- and extrahepatic bile duct system. PSC patients have an increased risk to develop hepatobiliary as well as extrahepatic malignancies. The goal of a surveillance strategy for hepatobiliary malignancy in these patients is the detection of early cancer which will allow a potentially curative therapy. Here, we focus on a conceptual review of the pathogenesis of cholangiocellular carcinoma and gallbladder cancer and we will discuss a rational approach for the surveillance of these malignancies in PSC patients.",
keywords = "Bile Duct Neoplasms, Bile Ducts, Intrahepatic, Cholangiocarcinoma, Cholangitis, Sclerosing, Diagnostic Techniques, Digestive System, Gallbladder Neoplasms, Humans",
author = "Hanno Ehlken and Christoph Schramm",
note = "Copyright {\textcopyright} 2013 S. Karger AG, Basel.",
year = "2013",
month = jan,
day = "1",
doi = "10.1159/000347206",
language = "English",
volume = "31",
pages = "118--25",
journal = "DIGEST DIS",
issn = "0257-2753",
publisher = "S. Karger AG",
number = "1",

}

RIS

TY - JOUR

T1 - Primary sclerosing cholangitis and cholangiocarcinoma: pathogenesis and modes of diagnostics

AU - Ehlken, Hanno

AU - Schramm, Christoph

N1 - Copyright © 2013 S. Karger AG, Basel.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease caused by progressive inflammation of the intra- and extrahepatic bile duct system. PSC patients have an increased risk to develop hepatobiliary as well as extrahepatic malignancies. The goal of a surveillance strategy for hepatobiliary malignancy in these patients is the detection of early cancer which will allow a potentially curative therapy. Here, we focus on a conceptual review of the pathogenesis of cholangiocellular carcinoma and gallbladder cancer and we will discuss a rational approach for the surveillance of these malignancies in PSC patients.

AB - Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease caused by progressive inflammation of the intra- and extrahepatic bile duct system. PSC patients have an increased risk to develop hepatobiliary as well as extrahepatic malignancies. The goal of a surveillance strategy for hepatobiliary malignancy in these patients is the detection of early cancer which will allow a potentially curative therapy. Here, we focus on a conceptual review of the pathogenesis of cholangiocellular carcinoma and gallbladder cancer and we will discuss a rational approach for the surveillance of these malignancies in PSC patients.

KW - Bile Duct Neoplasms

KW - Bile Ducts, Intrahepatic

KW - Cholangiocarcinoma

KW - Cholangitis, Sclerosing

KW - Diagnostic Techniques, Digestive System

KW - Gallbladder Neoplasms

KW - Humans

U2 - 10.1159/000347206

DO - 10.1159/000347206

M3 - SCORING: Journal article

C2 - 23797133

VL - 31

SP - 118

EP - 125

JO - DIGEST DIS

JF - DIGEST DIS

SN - 0257-2753

IS - 1

ER -