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Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.

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Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling. / Duncker, Dirk J; Boontje, Nicky M; Merkus, Daphne; Versteilen, Amanda; Krysiak, Judith; Mearini, Giulia; El-Armouche, Ali; Beer, de; Vincent, J; Carrier, Lucie; Carrier, Lucie; Walker, Lori A; Linke, Wolfgang A; Stienen, Ger J M; van der Velden, Jolanda.

In: CIRC-HEART FAIL, Vol. 2, No. 3, 3, 2009, p. 233-242.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Duncker, DJ, Boontje, NM, Merkus, D, Versteilen, A, Krysiak, J, Mearini, G, El-Armouche, A, Beer, D, Vincent, J, Carrier, L, Carrier, L, Walker, LA, Linke, WA, Stienen, GJM & van der Velden, J 2009, 'Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.', CIRC-HEART FAIL, vol. 2, no. 3, 3, pp. 233-242. <http://www.ncbi.nlm.nih.gov/pubmed/19808345?dopt=Citation>

APA

Duncker, D. J., Boontje, N. M., Merkus, D., Versteilen, A., Krysiak, J., Mearini, G., El-Armouche, A., Beer, D., Vincent, J., Carrier, L., Carrier, L., Walker, L. A., Linke, W. A., Stienen, G. J. M., & van der Velden, J. (2009). Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling. CIRC-HEART FAIL, 2(3), 233-242. [3]. http://www.ncbi.nlm.nih.gov/pubmed/19808345?dopt=Citation

Vancouver

Duncker DJ, Boontje NM, Merkus D, Versteilen A, Krysiak J, Mearini G et al. Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling. CIRC-HEART FAIL. 2009;2(3):233-242. 3.

Bibtex

@article{3aa24d1fc2fd4f0c900e452c1f47d144,
title = "Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.",
abstract = "BACKGROUND: Myofilament contractility of individual cardiomyocytes is depressed in remote noninfarcted myocardium and contributes to global left ventricular pump dysfunction after myocardial infarction (MI). Here, we investigated whether beta-blocker therapy could restore myofilament contractility. METHODS AND RESULTS: In pigs with a MI induced by ligation of the left circumflex coronary artery, beta-blocker therapy (bisoprolol, MI+beta) was initiated on the first day after MI. Remote left ventricular subendocardial biopsies were taken 3 weeks after sham or MI surgery. Isometric force was measured in single permeabilized cardiomyocytes. Maximal force (F(max)) was lower, whereas Ca(2+) sensitivity was higher in untreated MI compared with sham (both P",
author = "Duncker, {Dirk J} and Boontje, {Nicky M} and Daphne Merkus and Amanda Versteilen and Judith Krysiak and Giulia Mearini and Ali El-Armouche and de Beer and J Vincent and Lucie Carrier and Lucie Carrier and Walker, {Lori A} and Linke, {Wolfgang A} and Stienen, {Ger J M} and {van der Velden}, Jolanda",
year = "2009",
language = "Deutsch",
volume = "2",
pages = "233--242",
journal = "CIRC-HEART FAIL",
issn = "1941-3289",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "3",

}

RIS

TY - JOUR

T1 - Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.

AU - Duncker, Dirk J

AU - Boontje, Nicky M

AU - Merkus, Daphne

AU - Versteilen, Amanda

AU - Krysiak, Judith

AU - Mearini, Giulia

AU - El-Armouche, Ali

AU - Beer, de

AU - Vincent, J

AU - Carrier, Lucie

AU - Carrier, Lucie

AU - Walker, Lori A

AU - Linke, Wolfgang A

AU - Stienen, Ger J M

AU - van der Velden, Jolanda

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Myofilament contractility of individual cardiomyocytes is depressed in remote noninfarcted myocardium and contributes to global left ventricular pump dysfunction after myocardial infarction (MI). Here, we investigated whether beta-blocker therapy could restore myofilament contractility. METHODS AND RESULTS: In pigs with a MI induced by ligation of the left circumflex coronary artery, beta-blocker therapy (bisoprolol, MI+beta) was initiated on the first day after MI. Remote left ventricular subendocardial biopsies were taken 3 weeks after sham or MI surgery. Isometric force was measured in single permeabilized cardiomyocytes. Maximal force (F(max)) was lower, whereas Ca(2+) sensitivity was higher in untreated MI compared with sham (both P

AB - BACKGROUND: Myofilament contractility of individual cardiomyocytes is depressed in remote noninfarcted myocardium and contributes to global left ventricular pump dysfunction after myocardial infarction (MI). Here, we investigated whether beta-blocker therapy could restore myofilament contractility. METHODS AND RESULTS: In pigs with a MI induced by ligation of the left circumflex coronary artery, beta-blocker therapy (bisoprolol, MI+beta) was initiated on the first day after MI. Remote left ventricular subendocardial biopsies were taken 3 weeks after sham or MI surgery. Isometric force was measured in single permeabilized cardiomyocytes. Maximal force (F(max)) was lower, whereas Ca(2+) sensitivity was higher in untreated MI compared with sham (both P

M3 - SCORING: Zeitschriftenaufsatz

VL - 2

SP - 233

EP - 242

JO - CIRC-HEART FAIL

JF - CIRC-HEART FAIL

SN - 1941-3289

IS - 3

M1 - 3

ER -