Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.
Standard
Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling. / Duncker, Dirk J; Boontje, Nicky M; Merkus, Daphne; Versteilen, Amanda; Krysiak, Judith; Mearini, Giulia; El-Armouche, Ali; Beer, de; Vincent, J; Carrier, Lucie; Carrier, Lucie; Walker, Lori A; Linke, Wolfgang A; Stienen, Ger J M; van der Velden, Jolanda.
in: CIRC-HEART FAIL, Jahrgang 2, Nr. 3, 3, 2009, S. 233-242.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.
AU - Duncker, Dirk J
AU - Boontje, Nicky M
AU - Merkus, Daphne
AU - Versteilen, Amanda
AU - Krysiak, Judith
AU - Mearini, Giulia
AU - El-Armouche, Ali
AU - Beer, de
AU - Vincent, J
AU - Carrier, Lucie
AU - Carrier, Lucie
AU - Walker, Lori A
AU - Linke, Wolfgang A
AU - Stienen, Ger J M
AU - van der Velden, Jolanda
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Myofilament contractility of individual cardiomyocytes is depressed in remote noninfarcted myocardium and contributes to global left ventricular pump dysfunction after myocardial infarction (MI). Here, we investigated whether beta-blocker therapy could restore myofilament contractility. METHODS AND RESULTS: In pigs with a MI induced by ligation of the left circumflex coronary artery, beta-blocker therapy (bisoprolol, MI+beta) was initiated on the first day after MI. Remote left ventricular subendocardial biopsies were taken 3 weeks after sham or MI surgery. Isometric force was measured in single permeabilized cardiomyocytes. Maximal force (F(max)) was lower, whereas Ca(2+) sensitivity was higher in untreated MI compared with sham (both P
AB - BACKGROUND: Myofilament contractility of individual cardiomyocytes is depressed in remote noninfarcted myocardium and contributes to global left ventricular pump dysfunction after myocardial infarction (MI). Here, we investigated whether beta-blocker therapy could restore myofilament contractility. METHODS AND RESULTS: In pigs with a MI induced by ligation of the left circumflex coronary artery, beta-blocker therapy (bisoprolol, MI+beta) was initiated on the first day after MI. Remote left ventricular subendocardial biopsies were taken 3 weeks after sham or MI surgery. Isometric force was measured in single permeabilized cardiomyocytes. Maximal force (F(max)) was lower, whereas Ca(2+) sensitivity was higher in untreated MI compared with sham (both P
M3 - SCORING: Zeitschriftenaufsatz
VL - 2
SP - 233
EP - 242
JO - CIRC-HEART FAIL
JF - CIRC-HEART FAIL
SN - 1941-3289
IS - 3
M1 - 3
ER -