Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
Standard
Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue. / Angin, Mathieu; Kwon, Douglas S; Streeck, Hendrik; Wen, Fang; King, Melanie; Rezai, Ashley; Law, Kenneth; Hongo, Tomoyuki C; Pyo, Augustine; Piechocka-Trocha, Alicja; Toth, Ildiko; Pereyra, Florencia; Ghebremichael, Musie; Rodig, Scott J; Milner, Danny A; Richter, James M; Altfeld, Marcus; Kaufmann, Daniel E; Walker, Bruce D; Addo, Marylyn.
In: J INFECT DIS, Vol. 205, No. 10, 10, 2012, p. 1495-1500.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
AU - Angin, Mathieu
AU - Kwon, Douglas S
AU - Streeck, Hendrik
AU - Wen, Fang
AU - King, Melanie
AU - Rezai, Ashley
AU - Law, Kenneth
AU - Hongo, Tomoyuki C
AU - Pyo, Augustine
AU - Piechocka-Trocha, Alicja
AU - Toth, Ildiko
AU - Pereyra, Florencia
AU - Ghebremichael, Musie
AU - Rodig, Scott J
AU - Milner, Danny A
AU - Richter, James M
AU - Altfeld, Marcus
AU - Kaufmann, Daniel E
AU - Walker, Bruce D
AU - Addo, Marylyn
PY - 2012
Y1 - 2012
N2 - Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV "elite controllers" and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.
AB - Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV "elite controllers" and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.
KW - Humans
KW - Cohort Studies
KW - Disease Progression
KW - Chronic Disease
KW - Viral Load
KW - Case-Control Studies
KW - Flow Cytometry
KW - Lymphocyte Count
KW - RNA, Viral/blood
KW - HIV-1/immunology
KW - HIV Infections/immunology/virology
KW - Lymphoid Tissue/immunology
KW - T-Lymphocytes, Regulatory/immunology/physiology/virology
KW - Humans
KW - Cohort Studies
KW - Disease Progression
KW - Chronic Disease
KW - Viral Load
KW - Case-Control Studies
KW - Flow Cytometry
KW - Lymphocyte Count
KW - RNA, Viral/blood
KW - HIV-1/immunology
KW - HIV Infections/immunology/virology
KW - Lymphoid Tissue/immunology
KW - T-Lymphocytes, Regulatory/immunology/physiology/virology
M3 - SCORING: Journal article
VL - 205
SP - 1495
EP - 1500
JO - J INFECT DIS
JF - J INFECT DIS
SN - 0022-1899
IS - 10
M1 - 10
ER -