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Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.

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Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue. / Angin, Mathieu; Kwon, Douglas S; Streeck, Hendrik; Wen, Fang; King, Melanie; Rezai, Ashley; Law, Kenneth; Hongo, Tomoyuki C; Pyo, Augustine; Piechocka-Trocha, Alicja; Toth, Ildiko; Pereyra, Florencia; Ghebremichael, Musie; Rodig, Scott J; Milner, Danny A; Richter, James M; Altfeld, Marcus; Kaufmann, Daniel E; Walker, Bruce D; Addo, Marylyn.

in: J INFECT DIS, Jahrgang 205, Nr. 10, 10, 2012, S. 1495-1500.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Angin, M, Kwon, DS, Streeck, H, Wen, F, King, M, Rezai, A, Law, K, Hongo, TC, Pyo, A, Piechocka-Trocha, A, Toth, I, Pereyra, F, Ghebremichael, M, Rodig, SJ, Milner, DA, Richter, JM, Altfeld, M, Kaufmann, DE, Walker, BD & Addo, M 2012, 'Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.', J INFECT DIS, Jg. 205, Nr. 10, 10, S. 1495-1500. <http://www.ncbi.nlm.nih.gov/pubmed/22427677?dopt=Citation>

APA

Angin, M., Kwon, D. S., Streeck, H., Wen, F., King, M., Rezai, A., Law, K., Hongo, T. C., Pyo, A., Piechocka-Trocha, A., Toth, I., Pereyra, F., Ghebremichael, M., Rodig, S. J., Milner, D. A., Richter, J. M., Altfeld, M., Kaufmann, D. E., Walker, B. D., & Addo, M. (2012). Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue. J INFECT DIS, 205(10), 1495-1500. [10]. http://www.ncbi.nlm.nih.gov/pubmed/22427677?dopt=Citation

Vancouver

Angin M, Kwon DS, Streeck H, Wen F, King M, Rezai A et al. Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue. J INFECT DIS. 2012;205(10):1495-1500. 10.

Bibtex

@article{2ff5384ebe2b43b196a86fbeb0b6c24f,
title = "Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.",
abstract = "Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV {"}elite controllers{"} and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.",
keywords = "Humans, Cohort Studies, Disease Progression, Chronic Disease, Viral Load, Case-Control Studies, Flow Cytometry, Lymphocyte Count, RNA, Viral/blood, HIV-1/*immunology, HIV Infections/*immunology/virology, Lymphoid Tissue/immunology, T-Lymphocytes, Regulatory/immunology/*physiology/virology, Humans, Cohort Studies, Disease Progression, Chronic Disease, Viral Load, Case-Control Studies, Flow Cytometry, Lymphocyte Count, RNA, Viral/blood, HIV-1/*immunology, HIV Infections/*immunology/virology, Lymphoid Tissue/immunology, T-Lymphocytes, Regulatory/immunology/*physiology/virology",
author = "Mathieu Angin and Kwon, {Douglas S} and Hendrik Streeck and Fang Wen and Melanie King and Ashley Rezai and Kenneth Law and Hongo, {Tomoyuki C} and Augustine Pyo and Alicja Piechocka-Trocha and Ildiko Toth and Florencia Pereyra and Musie Ghebremichael and Rodig, {Scott J} and Milner, {Danny A} and Richter, {James M} and Marcus Altfeld and Kaufmann, {Daniel E} and Walker, {Bruce D} and Marylyn Addo",
year = "2012",
language = "English",
volume = "205",
pages = "1495--1500",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",

}

RIS

TY - JOUR

T1 - Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.

AU - Angin, Mathieu

AU - Kwon, Douglas S

AU - Streeck, Hendrik

AU - Wen, Fang

AU - King, Melanie

AU - Rezai, Ashley

AU - Law, Kenneth

AU - Hongo, Tomoyuki C

AU - Pyo, Augustine

AU - Piechocka-Trocha, Alicja

AU - Toth, Ildiko

AU - Pereyra, Florencia

AU - Ghebremichael, Musie

AU - Rodig, Scott J

AU - Milner, Danny A

AU - Richter, James M

AU - Altfeld, Marcus

AU - Kaufmann, Daniel E

AU - Walker, Bruce D

AU - Addo, Marylyn

PY - 2012

Y1 - 2012

N2 - Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV "elite controllers" and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.

AB - Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV "elite controllers" and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.

KW - Humans

KW - Cohort Studies

KW - Disease Progression

KW - Chronic Disease

KW - Viral Load

KW - Case-Control Studies

KW - Flow Cytometry

KW - Lymphocyte Count

KW - RNA, Viral/blood

KW - HIV-1/immunology

KW - HIV Infections/immunology/virology

KW - Lymphoid Tissue/immunology

KW - T-Lymphocytes, Regulatory/immunology/physiology/virology

KW - Humans

KW - Cohort Studies

KW - Disease Progression

KW - Chronic Disease

KW - Viral Load

KW - Case-Control Studies

KW - Flow Cytometry

KW - Lymphocyte Count

KW - RNA, Viral/blood

KW - HIV-1/immunology

KW - HIV Infections/immunology/virology

KW - Lymphoid Tissue/immunology

KW - T-Lymphocytes, Regulatory/immunology/physiology/virology

M3 - SCORING: Journal article

VL - 205

SP - 1495

EP - 1500

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 10

M1 - 10

ER -