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PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel, and CMF versus a standard-dosed epirubicin-cyclophosphamide followed by paclitaxel with or without darbepoetin alfa in primary breast cancer--outcome on prognosis.

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PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel, and CMF versus a standard-dosed epirubicin-cyclophosphamide followed by paclitaxel with or without darbepoetin alfa in primary breast cancer--outcome on prognosis. / Untch, M; von Minckwitz, G; Konecny, G E; Conrad, U; Fett, W; Kurzeder, C; Lück, H-J; Stickeler, E; Urbaczyk, H; Liedtke, B; Beckmann, M W; Salat, C; Harbeck, N; Müller, Volkmar; Schmidt, M; Hasmüller, S; Lenhard, M; Nekljudova, V; Lebeau, Annette; Loibl, S; Fasching, P A; Investigators, Arbeitsgemeinschaft Gynäkologische Onkologie PREPARE.

In: ANN ONCOL, Vol. 22, No. 9, 9, 2011, p. 1999-2006.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Untch, M, von Minckwitz, G, Konecny, GE, Conrad, U, Fett, W, Kurzeder, C, Lück, H-J, Stickeler, E, Urbaczyk, H, Liedtke, B, Beckmann, MW, Salat, C, Harbeck, N, Müller, V, Schmidt, M, Hasmüller, S, Lenhard, M, Nekljudova, V, Lebeau, A, Loibl, S, Fasching, PA & Investigators, AGOPREPARE 2011, 'PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel, and CMF versus a standard-dosed epirubicin-cyclophosphamide followed by paclitaxel with or without darbepoetin alfa in primary breast cancer--outcome on prognosis.', ANN ONCOL, vol. 22, no. 9, 9, pp. 1999-2006. <http://www.ncbi.nlm.nih.gov/pubmed/21382868?dopt=Citation>

APA

Untch, M., von Minckwitz, G., Konecny, G. E., Conrad, U., Fett, W., Kurzeder, C., Lück, H-J., Stickeler, E., Urbaczyk, H., Liedtke, B., Beckmann, M. W., Salat, C., Harbeck, N., Müller, V., Schmidt, M., Hasmüller, S., Lenhard, M., Nekljudova, V., Lebeau, A., ... Investigators, A. G. O. PREPARE. (2011). PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel, and CMF versus a standard-dosed epirubicin-cyclophosphamide followed by paclitaxel with or without darbepoetin alfa in primary breast cancer--outcome on prognosis. ANN ONCOL, 22(9), 1999-2006. [9]. http://www.ncbi.nlm.nih.gov/pubmed/21382868?dopt=Citation

Vancouver

Untch M, von Minckwitz G, Konecny GE, Conrad U, Fett W, Kurzeder C et al. PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel, and CMF versus a standard-dosed epirubicin-cyclophosphamide followed by paclitaxel with or without darbepoetin alfa in primary breast cancer--outcome on prognosis. ANN ONCOL. 2011;22(9):1999-2006. 9.

Bibtex

@article{df94a664499e433486d76d79569de7f9,
title = "PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel, and CMF versus a standard-dosed epirubicin-cyclophosphamide followed by paclitaxel with or without darbepoetin alfa in primary breast cancer--outcome on prognosis.",
abstract = "The objective of this study was to compare the effect of dose-intensified neoadjuvant chemotherapy with that of standard epirubicin plus cyclophosphamide followed by paclitaxel in combination with or without darbepoetin on survival in primary breast cancer.",
keywords = "Adult, Humans, Aged, Female, Middle Aged, Young Adult, Multivariate Analysis, Treatment Outcome, Disease-Free Survival, Patient Compliance, Neoadjuvant Therapy, Chemotherapy, Adjuvant, Dose-Response Relationship, Drug, Preoperative Care, Cyclophosphamide/administration & dosage/adverse effects, Epirubicin/administration & dosage/adverse effects, Erythropoietin/administration & dosage/analogs & derivatives, Fluorouracil/administration & dosage/adverse effects, Methotrexate/administration & dosage/adverse effects, Paclitaxel/administration & dosage/adverse effects, Anemia/drug therapy, Antineoplastic Combined Chemotherapy Protocols/administration & dosage/adverse effects, Breast Neoplasms/blood/*drug therapy/surgery, Adult, Humans, Aged, Female, Middle Aged, Young Adult, Multivariate Analysis, Treatment Outcome, Disease-Free Survival, Patient Compliance, Neoadjuvant Therapy, Chemotherapy, Adjuvant, Dose-Response Relationship, Drug, Preoperative Care, Cyclophosphamide/administration & dosage/adverse effects, Epirubicin/administration & dosage/adverse effects, Erythropoietin/administration & dosage/analogs & derivatives, Fluorouracil/administration & dosage/adverse effects, Methotrexate/administration & dosage/adverse effects, Paclitaxel/administration & dosage/adverse effects, Anemia/drug therapy, Antineoplastic Combined Chemotherapy Protocols/administration & dosage/adverse effects, Breast Neoplasms/blood/*drug therapy/surgery",
author = "M Untch and {von Minckwitz}, G and Konecny, {G E} and U Conrad and W Fett and C Kurzeder and H-J L{\"u}ck and E Stickeler and H Urbaczyk and B Liedtke and Beckmann, {M W} and C Salat and N Harbeck and Volkmar M{\"u}ller and M Schmidt and S Hasm{\"u}ller and M Lenhard and V Nekljudova and Annette Lebeau and S Loibl and Fasching, {P A} and Investigators, {Arbeitsgemeinschaft Gyn{\"a}kologische Onkologie PREPARE}",
year = "2011",
language = "English",
volume = "22",
pages = "1999--2006",
journal = "ANN ONCOL",
issn = "0923-7534",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - PREPARE trial: a randomized phase III trial comparing preoperative, dose-dense, dose-intensified chemotherapy with epirubicin, paclitaxel, and CMF versus a standard-dosed epirubicin-cyclophosphamide followed by paclitaxel with or without darbepoetin alfa in primary breast cancer--outcome on prognosis.

AU - Untch, M

AU - von Minckwitz, G

AU - Konecny, G E

AU - Conrad, U

AU - Fett, W

AU - Kurzeder, C

AU - Lück, H-J

AU - Stickeler, E

AU - Urbaczyk, H

AU - Liedtke, B

AU - Beckmann, M W

AU - Salat, C

AU - Harbeck, N

AU - Müller, Volkmar

AU - Schmidt, M

AU - Hasmüller, S

AU - Lenhard, M

AU - Nekljudova, V

AU - Lebeau, Annette

AU - Loibl, S

AU - Fasching, P A

AU - Investigators, Arbeitsgemeinschaft Gynäkologische Onkologie PREPARE

PY - 2011

Y1 - 2011

N2 - The objective of this study was to compare the effect of dose-intensified neoadjuvant chemotherapy with that of standard epirubicin plus cyclophosphamide followed by paclitaxel in combination with or without darbepoetin on survival in primary breast cancer.

AB - The objective of this study was to compare the effect of dose-intensified neoadjuvant chemotherapy with that of standard epirubicin plus cyclophosphamide followed by paclitaxel in combination with or without darbepoetin on survival in primary breast cancer.

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Young Adult

KW - Multivariate Analysis

KW - Treatment Outcome

KW - Disease-Free Survival

KW - Patient Compliance

KW - Neoadjuvant Therapy

KW - Chemotherapy, Adjuvant

KW - Dose-Response Relationship, Drug

KW - Preoperative Care

KW - Cyclophosphamide/administration & dosage/adverse effects

KW - Epirubicin/administration & dosage/adverse effects

KW - Erythropoietin/administration & dosage/analogs & derivatives

KW - Fluorouracil/administration & dosage/adverse effects

KW - Methotrexate/administration & dosage/adverse effects

KW - Paclitaxel/administration & dosage/adverse effects

KW - Anemia/drug therapy

KW - Antineoplastic Combined Chemotherapy Protocols/administration & dosage/adverse effects

KW - Breast Neoplasms/blood/drug therapy/surgery

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Young Adult

KW - Multivariate Analysis

KW - Treatment Outcome

KW - Disease-Free Survival

KW - Patient Compliance

KW - Neoadjuvant Therapy

KW - Chemotherapy, Adjuvant

KW - Dose-Response Relationship, Drug

KW - Preoperative Care

KW - Cyclophosphamide/administration & dosage/adverse effects

KW - Epirubicin/administration & dosage/adverse effects

KW - Erythropoietin/administration & dosage/analogs & derivatives

KW - Fluorouracil/administration & dosage/adverse effects

KW - Methotrexate/administration & dosage/adverse effects

KW - Paclitaxel/administration & dosage/adverse effects

KW - Anemia/drug therapy

KW - Antineoplastic Combined Chemotherapy Protocols/administration & dosage/adverse effects

KW - Breast Neoplasms/blood/drug therapy/surgery

M3 - SCORING: Journal article

VL - 22

SP - 1999

EP - 2006

JO - ANN ONCOL

JF - ANN ONCOL

SN - 0923-7534

IS - 9

M1 - 9

ER -