Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments
Standard
Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments. / Chen, Chen; Klämpfl, Florian; Knipfer, Christian; Riemann, Max; Kanawade, Rajesh; Stelzle, Florian; Schmidt, Michael.
In: BIOMED OPT EXPRESS, Vol. 5, No. 9, 01.09.2014, p. 3140-9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments
AU - Chen, Chen
AU - Klämpfl, Florian
AU - Knipfer, Christian
AU - Riemann, Max
AU - Kanawade, Rajesh
AU - Stelzle, Florian
AU - Schmidt, Michael
PY - 2014/9/1
Y1 - 2014/9/1
N2 - A popular alternative of preparing multilayer or microfluidic chip based phantoms could have helped to simulate the subsurface vascular network, but brought inevitable problems. In this work, we describe the preparation method of a single layer skin equivalent tissue phantom containing interior vessel channels, which mimick the superficial microvascular structure. The fabrication method does not disturb the optical properties of the turbiding matrix material. The diameter of the channels reaches a value of 50 μm. The size, as well as the geometry of the generated vessel structures are investigated by using the SD-OCT system. Our preliminary results confirm that fabrication of such a phantom is achievable and reproducible. Prospectively, this phantom is used to calibrate the optical angiographic imaging approaches.
AB - A popular alternative of preparing multilayer or microfluidic chip based phantoms could have helped to simulate the subsurface vascular network, but brought inevitable problems. In this work, we describe the preparation method of a single layer skin equivalent tissue phantom containing interior vessel channels, which mimick the superficial microvascular structure. The fabrication method does not disturb the optical properties of the turbiding matrix material. The diameter of the channels reaches a value of 50 μm. The size, as well as the geometry of the generated vessel structures are investigated by using the SD-OCT system. Our preliminary results confirm that fabrication of such a phantom is achievable and reproducible. Prospectively, this phantom is used to calibrate the optical angiographic imaging approaches.
KW - Journal Article
U2 - 10.1364/BOE.5.003140
DO - 10.1364/BOE.5.003140
M3 - SCORING: Journal article
C2 - 25401027
VL - 5
SP - 3140
EP - 3149
JO - BIOMED OPT EXPRESS
JF - BIOMED OPT EXPRESS
SN - 2156-7085
IS - 9
ER -