Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice
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Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice. / Engels, Géraldine; Hierweger, Alexandra Maximiliane; Hoffmann, Julia; Thieme, René; Thiele, Swantje; Bertram, Stephanie; Dreier, Carola; Resa-Infante, Patricia; Jacobsen, Henning; Thiele, Kristin; Alawi, Malik; Indenbirken, Daniela; Grundhoff, Adam; Siebels, Svenja; Fischer, Nicole; Stojanovska, Violeta; Muzzio, Damián; Jensen, Federico; Karimi, Khalil; Mittrücker, Hans-Willi; Arck, Petra Clara; Gabriel, Gülsah.
In: CELL HOST MICROBE, Vol. 21, No. 3, 08.03.2017, p. 321-333.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice
AU - Engels, Géraldine
AU - Hierweger, Alexandra Maximiliane
AU - Hoffmann, Julia
AU - Thieme, René
AU - Thiele, Swantje
AU - Bertram, Stephanie
AU - Dreier, Carola
AU - Resa-Infante, Patricia
AU - Jacobsen, Henning
AU - Thiele, Kristin
AU - Alawi, Malik
AU - Indenbirken, Daniela
AU - Grundhoff, Adam
AU - Siebels, Svenja
AU - Fischer, Nicole
AU - Stojanovska, Violeta
AU - Muzzio, Damián
AU - Jensen, Federico
AU - Karimi, Khalil
AU - Mittrücker, Hans-Willi
AU - Arck, Petra Clara
AU - Gabriel, Gülsah
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2017/3/8
Y1 - 2017/3/8
N2 - Pregnant women are at high risk for severe influenza disease outcomes, yet insights into the underlying mechanisms are limited. Here, we present models of H1N1 infection in syngenic and allogenic pregnant mice; infection in the latter mirrors the severe course of 2009 pandemic influenza in pregnant women. We found that the anti-viral immune response in the pregnant host was significantly restricted as compared to the non-pregnant host. This included a reduced type I interferon response as well as impaired migration of CD8(+) T cells into the lung. The multi-faceted failure to mount an anti-viral response in allogenic pregnant mice resulted in a less stringent selective environment that promoted the emergence of 2009 H1N1 virus variants that specifically counteract type I interferon response and mediate increased viral pathogenicity. These insights underscore the importance of influenza vaccination compliance in pregnant women and may open novel therapeutic avenues.
AB - Pregnant women are at high risk for severe influenza disease outcomes, yet insights into the underlying mechanisms are limited. Here, we present models of H1N1 infection in syngenic and allogenic pregnant mice; infection in the latter mirrors the severe course of 2009 pandemic influenza in pregnant women. We found that the anti-viral immune response in the pregnant host was significantly restricted as compared to the non-pregnant host. This included a reduced type I interferon response as well as impaired migration of CD8(+) T cells into the lung. The multi-faceted failure to mount an anti-viral response in allogenic pregnant mice resulted in a less stringent selective environment that promoted the emergence of 2009 H1N1 virus variants that specifically counteract type I interferon response and mediate increased viral pathogenicity. These insights underscore the importance of influenza vaccination compliance in pregnant women and may open novel therapeutic avenues.
KW - Journal Article
U2 - 10.1016/j.chom.2017.02.020
DO - 10.1016/j.chom.2017.02.020
M3 - SCORING: Journal article
C2 - 28279344
VL - 21
SP - 321
EP - 333
JO - CELL HOST MICROBE
JF - CELL HOST MICROBE
SN - 1931-3128
IS - 3
ER -