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Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice

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Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice. / Engels, Géraldine; Hierweger, Alexandra Maximiliane; Hoffmann, Julia; Thieme, René; Thiele, Swantje; Bertram, Stephanie; Dreier, Carola; Resa-Infante, Patricia; Jacobsen, Henning; Thiele, Kristin; Alawi, Malik; Indenbirken, Daniela; Grundhoff, Adam; Siebels, Svenja; Fischer, Nicole; Stojanovska, Violeta; Muzzio, Damián; Jensen, Federico; Karimi, Khalil; Mittrücker, Hans-Willi; Arck, Petra Clara; Gabriel, Gülsah.

in: CELL HOST MICROBE, Jahrgang 21, Nr. 3, 08.03.2017, S. 321-333.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Engels, G, Hierweger, AM, Hoffmann, J, Thieme, R, Thiele, S, Bertram, S, Dreier, C, Resa-Infante, P, Jacobsen, H, Thiele, K, Alawi, M, Indenbirken, D, Grundhoff, A, Siebels, S, Fischer, N, Stojanovska, V, Muzzio, D, Jensen, F, Karimi, K, Mittrücker, H-W, Arck, PC & Gabriel, G 2017, 'Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice', CELL HOST MICROBE, Jg. 21, Nr. 3, S. 321-333. https://doi.org/10.1016/j.chom.2017.02.020

APA

Engels, G., Hierweger, A. M., Hoffmann, J., Thieme, R., Thiele, S., Bertram, S., Dreier, C., Resa-Infante, P., Jacobsen, H., Thiele, K., Alawi, M., Indenbirken, D., Grundhoff, A., Siebels, S., Fischer, N., Stojanovska, V., Muzzio, D., Jensen, F., Karimi, K., ... Gabriel, G. (2017). Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice. CELL HOST MICROBE, 21(3), 321-333. https://doi.org/10.1016/j.chom.2017.02.020

Vancouver

Engels G, Hierweger AM, Hoffmann J, Thieme R, Thiele S, Bertram S et al. Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice. CELL HOST MICROBE. 2017 Mär 8;21(3):321-333. https://doi.org/10.1016/j.chom.2017.02.020

Bibtex

@article{9f95af2bafa84bb08d5f18a44cf01ba4,
title = "Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice",
abstract = "Pregnant women are at high risk for severe influenza disease outcomes, yet insights into the underlying mechanisms are limited. Here, we present models of H1N1 infection in syngenic and allogenic pregnant mice; infection in the latter mirrors the severe course of 2009 pandemic influenza in pregnant women. We found that the anti-viral immune response in the pregnant host was significantly restricted as compared to the non-pregnant host. This included a reduced type I interferon response as well as impaired migration of CD8(+) T cells into the lung. The multi-faceted failure to mount an anti-viral response in allogenic pregnant mice resulted in a less stringent selective environment that promoted the emergence of 2009 H1N1 virus variants that specifically counteract type I interferon response and mediate increased viral pathogenicity. These insights underscore the importance of influenza vaccination compliance in pregnant women and may open novel therapeutic avenues.",
keywords = "Journal Article",
author = "G{\'e}raldine Engels and Hierweger, {Alexandra Maximiliane} and Julia Hoffmann and Ren{\'e} Thieme and Swantje Thiele and Stephanie Bertram and Carola Dreier and Patricia Resa-Infante and Henning Jacobsen and Kristin Thiele and Malik Alawi and Daniela Indenbirken and Adam Grundhoff and Svenja Siebels and Nicole Fischer and Violeta Stojanovska and Dami{\'a}n Muzzio and Federico Jensen and Khalil Karimi and Hans-Willi Mittr{\"u}cker and Arck, {Petra Clara} and G{\"u}lsah Gabriel",
note = "Copyright {\textcopyright} 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = mar,
day = "8",
doi = "10.1016/j.chom.2017.02.020",
language = "English",
volume = "21",
pages = "321--333",
journal = "CELL HOST MICROBE",
issn = "1931-3128",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice

AU - Engels, Géraldine

AU - Hierweger, Alexandra Maximiliane

AU - Hoffmann, Julia

AU - Thieme, René

AU - Thiele, Swantje

AU - Bertram, Stephanie

AU - Dreier, Carola

AU - Resa-Infante, Patricia

AU - Jacobsen, Henning

AU - Thiele, Kristin

AU - Alawi, Malik

AU - Indenbirken, Daniela

AU - Grundhoff, Adam

AU - Siebels, Svenja

AU - Fischer, Nicole

AU - Stojanovska, Violeta

AU - Muzzio, Damián

AU - Jensen, Federico

AU - Karimi, Khalil

AU - Mittrücker, Hans-Willi

AU - Arck, Petra Clara

AU - Gabriel, Gülsah

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/3/8

Y1 - 2017/3/8

N2 - Pregnant women are at high risk for severe influenza disease outcomes, yet insights into the underlying mechanisms are limited. Here, we present models of H1N1 infection in syngenic and allogenic pregnant mice; infection in the latter mirrors the severe course of 2009 pandemic influenza in pregnant women. We found that the anti-viral immune response in the pregnant host was significantly restricted as compared to the non-pregnant host. This included a reduced type I interferon response as well as impaired migration of CD8(+) T cells into the lung. The multi-faceted failure to mount an anti-viral response in allogenic pregnant mice resulted in a less stringent selective environment that promoted the emergence of 2009 H1N1 virus variants that specifically counteract type I interferon response and mediate increased viral pathogenicity. These insights underscore the importance of influenza vaccination compliance in pregnant women and may open novel therapeutic avenues.

AB - Pregnant women are at high risk for severe influenza disease outcomes, yet insights into the underlying mechanisms are limited. Here, we present models of H1N1 infection in syngenic and allogenic pregnant mice; infection in the latter mirrors the severe course of 2009 pandemic influenza in pregnant women. We found that the anti-viral immune response in the pregnant host was significantly restricted as compared to the non-pregnant host. This included a reduced type I interferon response as well as impaired migration of CD8(+) T cells into the lung. The multi-faceted failure to mount an anti-viral response in allogenic pregnant mice resulted in a less stringent selective environment that promoted the emergence of 2009 H1N1 virus variants that specifically counteract type I interferon response and mediate increased viral pathogenicity. These insights underscore the importance of influenza vaccination compliance in pregnant women and may open novel therapeutic avenues.

KW - Journal Article

U2 - 10.1016/j.chom.2017.02.020

DO - 10.1016/j.chom.2017.02.020

M3 - SCORING: Journal article

C2 - 28279344

VL - 21

SP - 321

EP - 333

JO - CELL HOST MICROBE

JF - CELL HOST MICROBE

SN - 1931-3128

IS - 3

ER -