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Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice

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Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice. / Yüzen, Dennis; Urbschat, Christopher; Schepanski, Steven; Thiele, Kristin; Arck, Petra C; Mittrücker, Hans-Willi.

In: EMBO REP, Vol. 24, No. 10, e56829, 09.10.2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Yüzen, D, Urbschat, C, Schepanski, S, Thiele, K, Arck, PC & Mittrücker, H-W 2023, 'Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice', EMBO REP, vol. 24, no. 10, e56829. https://doi.org/10.15252/embr.202356829

APA

Yüzen, D., Urbschat, C., Schepanski, S., Thiele, K., Arck, P. C., & Mittrücker, H-W. (2023). Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice. EMBO REP, 24(10), [e56829]. https://doi.org/10.15252/embr.202356829

Vancouver

Yüzen D, Urbschat C, Schepanski S, Thiele K, Arck PC, Mittrücker H-W. Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice. EMBO REP. 2023 Oct 9;24(10). e56829. https://doi.org/10.15252/embr.202356829

Bibtex

@article{d3c59e6020d9467db6016ce8cd05bba1,
title = "Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice",
abstract = "Neonatal health is determined by the transfer of maternal antibodies from the mother to the fetus. Besides antibodies, maternal cells cross the placental barrier and seed into fetal organs. Contrary to maternal antibodies, maternal microchimeric cells (MMc) show a high longevity, as they can persist in the offspring until adulthood. Recent evidence highlights that MMc leukocytes promote neonatal immunity against early-life infections in mice and humans. As shown in mice, this promotion of immunity was attributable to an improved fetal immune development. Besides this indirect effect, MMc may be pathogen-specific and thus, directly clear pathogen threats in the offspring postnatally. By using ovalbumin recombinant Listeria monocytogenes (LmOVA), we here provide evidence that OVA-specific T cells are transferred from the mother to the fetus, which is associated with increased activation of T cells and a milder course of postnatal infection in the offspring. Our data highlight that maternally-derived passive immunity of the neonate is not limited to antibodies, as MMc have the potential to transfer immune memory between generations.",
author = "Dennis Y{\"u}zen and Christopher Urbschat and Steven Schepanski and Kristin Thiele and Arck, {Petra C} and Hans-Willi Mittr{\"u}cker",
note = "{\textcopyright} 2023 The Authors. Published under the terms of the CC BY 4.0 license.",
year = "2023",
month = oct,
day = "9",
doi = "10.15252/embr.202356829",
language = "English",
volume = "24",
journal = "EMBO REP",
issn = "1469-221X",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice

AU - Yüzen, Dennis

AU - Urbschat, Christopher

AU - Schepanski, Steven

AU - Thiele, Kristin

AU - Arck, Petra C

AU - Mittrücker, Hans-Willi

N1 - © 2023 The Authors. Published under the terms of the CC BY 4.0 license.

PY - 2023/10/9

Y1 - 2023/10/9

N2 - Neonatal health is determined by the transfer of maternal antibodies from the mother to the fetus. Besides antibodies, maternal cells cross the placental barrier and seed into fetal organs. Contrary to maternal antibodies, maternal microchimeric cells (MMc) show a high longevity, as they can persist in the offspring until adulthood. Recent evidence highlights that MMc leukocytes promote neonatal immunity against early-life infections in mice and humans. As shown in mice, this promotion of immunity was attributable to an improved fetal immune development. Besides this indirect effect, MMc may be pathogen-specific and thus, directly clear pathogen threats in the offspring postnatally. By using ovalbumin recombinant Listeria monocytogenes (LmOVA), we here provide evidence that OVA-specific T cells are transferred from the mother to the fetus, which is associated with increased activation of T cells and a milder course of postnatal infection in the offspring. Our data highlight that maternally-derived passive immunity of the neonate is not limited to antibodies, as MMc have the potential to transfer immune memory between generations.

AB - Neonatal health is determined by the transfer of maternal antibodies from the mother to the fetus. Besides antibodies, maternal cells cross the placental barrier and seed into fetal organs. Contrary to maternal antibodies, maternal microchimeric cells (MMc) show a high longevity, as they can persist in the offspring until adulthood. Recent evidence highlights that MMc leukocytes promote neonatal immunity against early-life infections in mice and humans. As shown in mice, this promotion of immunity was attributable to an improved fetal immune development. Besides this indirect effect, MMc may be pathogen-specific and thus, directly clear pathogen threats in the offspring postnatally. By using ovalbumin recombinant Listeria monocytogenes (LmOVA), we here provide evidence that OVA-specific T cells are transferred from the mother to the fetus, which is associated with increased activation of T cells and a milder course of postnatal infection in the offspring. Our data highlight that maternally-derived passive immunity of the neonate is not limited to antibodies, as MMc have the potential to transfer immune memory between generations.

U2 - 10.15252/embr.202356829

DO - 10.15252/embr.202356829

M3 - SCORING: Journal article

C2 - 37610043

VL - 24

JO - EMBO REP

JF - EMBO REP

SN - 1469-221X

IS - 10

M1 - e56829

ER -