Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice
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Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice. / Yüzen, Dennis; Urbschat, Christopher; Schepanski, Steven; Thiele, Kristin; Arck, Petra C; Mittrücker, Hans-Willi.
in: EMBO REP, Jahrgang 24, Nr. 10, e56829, 09.10.2023.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice
AU - Yüzen, Dennis
AU - Urbschat, Christopher
AU - Schepanski, Steven
AU - Thiele, Kristin
AU - Arck, Petra C
AU - Mittrücker, Hans-Willi
N1 - © 2023 The Authors. Published under the terms of the CC BY 4.0 license.
PY - 2023/10/9
Y1 - 2023/10/9
N2 - Neonatal health is determined by the transfer of maternal antibodies from the mother to the fetus. Besides antibodies, maternal cells cross the placental barrier and seed into fetal organs. Contrary to maternal antibodies, maternal microchimeric cells (MMc) show a high longevity, as they can persist in the offspring until adulthood. Recent evidence highlights that MMc leukocytes promote neonatal immunity against early-life infections in mice and humans. As shown in mice, this promotion of immunity was attributable to an improved fetal immune development. Besides this indirect effect, MMc may be pathogen-specific and thus, directly clear pathogen threats in the offspring postnatally. By using ovalbumin recombinant Listeria monocytogenes (LmOVA), we here provide evidence that OVA-specific T cells are transferred from the mother to the fetus, which is associated with increased activation of T cells and a milder course of postnatal infection in the offspring. Our data highlight that maternally-derived passive immunity of the neonate is not limited to antibodies, as MMc have the potential to transfer immune memory between generations.
AB - Neonatal health is determined by the transfer of maternal antibodies from the mother to the fetus. Besides antibodies, maternal cells cross the placental barrier and seed into fetal organs. Contrary to maternal antibodies, maternal microchimeric cells (MMc) show a high longevity, as they can persist in the offspring until adulthood. Recent evidence highlights that MMc leukocytes promote neonatal immunity against early-life infections in mice and humans. As shown in mice, this promotion of immunity was attributable to an improved fetal immune development. Besides this indirect effect, MMc may be pathogen-specific and thus, directly clear pathogen threats in the offspring postnatally. By using ovalbumin recombinant Listeria monocytogenes (LmOVA), we here provide evidence that OVA-specific T cells are transferred from the mother to the fetus, which is associated with increased activation of T cells and a milder course of postnatal infection in the offspring. Our data highlight that maternally-derived passive immunity of the neonate is not limited to antibodies, as MMc have the potential to transfer immune memory between generations.
U2 - 10.15252/embr.202356829
DO - 10.15252/embr.202356829
M3 - SCORING: Journal article
C2 - 37610043
VL - 24
JO - EMBO REP
JF - EMBO REP
SN - 1469-221X
IS - 10
M1 - e56829
ER -