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Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study

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Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study. / Bickel, Christoph; Schnabel, Renate B; Zeller, Tanja; Lackner, Karl J; Rupprecht, Hans J; Blankenberg, Stefan; Sinning, Christoph; Westermann, Dirk.

In: BIOMARKERS, Vol. 22, No. 3-4, 16.01.2016, p. 210-218.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bickel, C, Schnabel, RB, Zeller, T, Lackner, KJ, Rupprecht, HJ, Blankenberg, S, Sinning, C & Westermann, D 2016, 'Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study', BIOMARKERS, vol. 22, no. 3-4, pp. 210-218. https://doi.org/10.3109/1354750X.2015.1130745

APA

Bickel, C., Schnabel, R. B., Zeller, T., Lackner, K. J., Rupprecht, H. J., Blankenberg, S., Sinning, C., & Westermann, D. (2016). Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study. BIOMARKERS, 22(3-4), 210-218. https://doi.org/10.3109/1354750X.2015.1130745

Vancouver

Bickel C, Schnabel RB, Zeller T, Lackner KJ, Rupprecht HJ, Blankenberg S et al. Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study. BIOMARKERS. 2016 Jan 16;22(3-4):210-218. https://doi.org/10.3109/1354750X.2015.1130745

Bibtex

@article{581e026d2bdb45f5b9ba0d4b56549d5d,
title = "Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study",
abstract = "CONTEXT: Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions.OBJECTIVE: The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N = 1907).METHODS: AtheroGene is a contemporary CAD cohort study (N = 3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years.RESULTS: Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR = 1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients.CONCLUSION: In women with known CAD, increased leptin concentration is useful for predicting cardiovascular death and non-fatal myocardial infarction.",
keywords = "Aged, Cardiovascular Diseases/blood, Cohort Studies, Coronary Artery Disease/complications, Female, Follow-Up Studies, Humans, Leptin/blood, Male, Middle Aged, Myocardial Infarction/diagnosis, Predictive Value of Tests, Proportional Hazards Models, Risk Assessment, Sex Factors",
author = "Christoph Bickel and Schnabel, {Renate B} and Tanja Zeller and Lackner, {Karl J} and Rupprecht, {Hans J} and Stefan Blankenberg and Christoph Sinning and Dirk Westermann",
year = "2016",
month = jan,
day = "16",
doi = "10.3109/1354750X.2015.1130745",
language = "English",
volume = "22",
pages = "210--218",
journal = "BIOMARKERS",
issn = "1354-750X",
publisher = "informa healthcare",
number = "3-4",

}

RIS

TY - JOUR

T1 - Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study

AU - Bickel, Christoph

AU - Schnabel, Renate B

AU - Zeller, Tanja

AU - Lackner, Karl J

AU - Rupprecht, Hans J

AU - Blankenberg, Stefan

AU - Sinning, Christoph

AU - Westermann, Dirk

PY - 2016/1/16

Y1 - 2016/1/16

N2 - CONTEXT: Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions.OBJECTIVE: The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N = 1907).METHODS: AtheroGene is a contemporary CAD cohort study (N = 3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years.RESULTS: Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR = 1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients.CONCLUSION: In women with known CAD, increased leptin concentration is useful for predicting cardiovascular death and non-fatal myocardial infarction.

AB - CONTEXT: Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions.OBJECTIVE: The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N = 1907).METHODS: AtheroGene is a contemporary CAD cohort study (N = 3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years.RESULTS: Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR = 1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients.CONCLUSION: In women with known CAD, increased leptin concentration is useful for predicting cardiovascular death and non-fatal myocardial infarction.

KW - Aged

KW - Cardiovascular Diseases/blood

KW - Cohort Studies

KW - Coronary Artery Disease/complications

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Leptin/blood

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/diagnosis

KW - Predictive Value of Tests

KW - Proportional Hazards Models

KW - Risk Assessment

KW - Sex Factors

U2 - 10.3109/1354750X.2015.1130745

DO - 10.3109/1354750X.2015.1130745

M3 - SCORING: Journal article

C2 - 26769430

VL - 22

SP - 210

EP - 218

JO - BIOMARKERS

JF - BIOMARKERS

SN - 1354-750X

IS - 3-4

ER -