Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study
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Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study. / Bickel, Christoph; Schnabel, Renate B; Zeller, Tanja; Lackner, Karl J; Rupprecht, Hans J; Blankenberg, Stefan; Sinning, Christoph; Westermann, Dirk.
in: BIOMARKERS, Jahrgang 22, Nr. 3-4, 16.01.2016, S. 210-218.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study
AU - Bickel, Christoph
AU - Schnabel, Renate B
AU - Zeller, Tanja
AU - Lackner, Karl J
AU - Rupprecht, Hans J
AU - Blankenberg, Stefan
AU - Sinning, Christoph
AU - Westermann, Dirk
PY - 2016/1/16
Y1 - 2016/1/16
N2 - CONTEXT: Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions.OBJECTIVE: The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N = 1907).METHODS: AtheroGene is a contemporary CAD cohort study (N = 3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years.RESULTS: Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR = 1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients.CONCLUSION: In women with known CAD, increased leptin concentration is useful for predicting cardiovascular death and non-fatal myocardial infarction.
AB - CONTEXT: Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions.OBJECTIVE: The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N = 1907).METHODS: AtheroGene is a contemporary CAD cohort study (N = 3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years.RESULTS: Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR = 1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients.CONCLUSION: In women with known CAD, increased leptin concentration is useful for predicting cardiovascular death and non-fatal myocardial infarction.
KW - Aged
KW - Cardiovascular Diseases/blood
KW - Cohort Studies
KW - Coronary Artery Disease/complications
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Leptin/blood
KW - Male
KW - Middle Aged
KW - Myocardial Infarction/diagnosis
KW - Predictive Value of Tests
KW - Proportional Hazards Models
KW - Risk Assessment
KW - Sex Factors
U2 - 10.3109/1354750X.2015.1130745
DO - 10.3109/1354750X.2015.1130745
M3 - SCORING: Journal article
C2 - 26769430
VL - 22
SP - 210
EP - 218
JO - BIOMARKERS
JF - BIOMARKERS
SN - 1354-750X
IS - 3-4
ER -