Preclinical study investigating the potential of low-dose-rate brachytherapy with P stents for the prevention of restenosis of paranasal neo-ostia

TY - JOUR

T1 - Preclinical study investigating the potential of low-dose-rate brachytherapy with P stents for the prevention of restenosis of paranasal neo-ostia

AU - Oestreicher, Elmar

AU - Bartsch, Harald

AU - Mayr, Doris

AU - Schubert, Mario

AU - Weber, Barbara

AU - Kneschaurek, Peter

AU - Assmann, Walter

AU - Sroka, Ronald

AU - Betz, Christian Stephan

N1 - Copyright © 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

PY - 2016/10/4

Y1 - 2016/10/4

N2 - PURPOSE: Ostial restenosis is a common cause of failures in paranasal sinus surgery. The aim of the current study was to investigate the use of low-dose-rate brachytherapy to prevent neo-ostial restenosis in an animal model.METHODS AND MATERIALS: In 14 rabbits, maxillary neo-ostia were created and measured. One side each was stented with a regular silicone stent, the other side was either not stented (n = 7) or stented with a phosphorous-32 implanted stent depositing a low-dose radiation of 15 Gy (n = 7) within 1 week, after which all stents were removed. After a period of additional 12 weeks of recovery, the animals were sacrificed, the neo-ostia were again measured, and the areas and histopathologic changes compared in between the groups.RESULTS: After 15-Gy stenting, the mean ostial areas were even slightly enlarged by 5.1% compared to the area at stent removal, whereas a significant reduction in area, indicating a process of restenosis, by 56.1% or 54.0% was seen in the control groups with no stent and normal stent, respectively. Furthermore, no indication for adverse histopathologic radiation effects was seen in the 15-Gy group.CONCLUSIONS: Low-dose-rate brachytherapy with phosphorous-32 doped silicone stents showed promising results in the prevention of neo-ostium restenosis in this proof-of-concept study, indicating that further preclinical and clinical testing may be warranted.

AB - PURPOSE: Ostial restenosis is a common cause of failures in paranasal sinus surgery. The aim of the current study was to investigate the use of low-dose-rate brachytherapy to prevent neo-ostial restenosis in an animal model.METHODS AND MATERIALS: In 14 rabbits, maxillary neo-ostia were created and measured. One side each was stented with a regular silicone stent, the other side was either not stented (n = 7) or stented with a phosphorous-32 implanted stent depositing a low-dose radiation of 15 Gy (n = 7) within 1 week, after which all stents were removed. After a period of additional 12 weeks of recovery, the animals were sacrificed, the neo-ostia were again measured, and the areas and histopathologic changes compared in between the groups.RESULTS: After 15-Gy stenting, the mean ostial areas were even slightly enlarged by 5.1% compared to the area at stent removal, whereas a significant reduction in area, indicating a process of restenosis, by 56.1% or 54.0% was seen in the control groups with no stent and normal stent, respectively. Furthermore, no indication for adverse histopathologic radiation effects was seen in the 15-Gy group.CONCLUSIONS: Low-dose-rate brachytherapy with phosphorous-32 doped silicone stents showed promising results in the prevention of neo-ostium restenosis in this proof-of-concept study, indicating that further preclinical and clinical testing may be warranted.

KW - Animals

KW - Brachytherapy

KW - Constriction, Pathologic

KW - Maxillary Sinus

KW - Paranasal Sinus Diseases

KW - Phosphorus Radioisotopes

KW - Postoperative Complications

KW - Rabbits

KW - Stents

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.brachy.2016.08.011

DO - 10.1016/j.brachy.2016.08.011

M3 - SCORING: Journal article

C2 - 27693170

VL - 16

SP - 207

EP - 214

JO - BRACHYTHERAPY

JF - BRACHYTHERAPY

SN - 1538-4721

IS - 1

ER -