Preclinical study investigating the potential of low-dose-rate brachytherapy with P stents for the prevention of restenosis of paranasal neo-ostia
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Preclinical study investigating the potential of low-dose-rate brachytherapy with P stents for the prevention of restenosis of paranasal neo-ostia. / Oestreicher, Elmar; Bartsch, Harald; Mayr, Doris; Schubert, Mario; Weber, Barbara; Kneschaurek, Peter; Assmann, Walter; Sroka, Ronald; Betz, Christian Stephan.
in: BRACHYTHERAPY, Jahrgang 16, Nr. 1, 04.10.2016, S. 207-214.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Preclinical study investigating the potential of low-dose-rate brachytherapy with P stents for the prevention of restenosis of paranasal neo-ostia
AU - Oestreicher, Elmar
AU - Bartsch, Harald
AU - Mayr, Doris
AU - Schubert, Mario
AU - Weber, Barbara
AU - Kneschaurek, Peter
AU - Assmann, Walter
AU - Sroka, Ronald
AU - Betz, Christian Stephan
N1 - Copyright © 2016 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
PY - 2016/10/4
Y1 - 2016/10/4
N2 - PURPOSE: Ostial restenosis is a common cause of failures in paranasal sinus surgery. The aim of the current study was to investigate the use of low-dose-rate brachytherapy to prevent neo-ostial restenosis in an animal model.METHODS AND MATERIALS: In 14 rabbits, maxillary neo-ostia were created and measured. One side each was stented with a regular silicone stent, the other side was either not stented (n = 7) or stented with a phosphorous-32 implanted stent depositing a low-dose radiation of 15 Gy (n = 7) within 1 week, after which all stents were removed. After a period of additional 12 weeks of recovery, the animals were sacrificed, the neo-ostia were again measured, and the areas and histopathologic changes compared in between the groups.RESULTS: After 15-Gy stenting, the mean ostial areas were even slightly enlarged by 5.1% compared to the area at stent removal, whereas a significant reduction in area, indicating a process of restenosis, by 56.1% or 54.0% was seen in the control groups with no stent and normal stent, respectively. Furthermore, no indication for adverse histopathologic radiation effects was seen in the 15-Gy group.CONCLUSIONS: Low-dose-rate brachytherapy with phosphorous-32 doped silicone stents showed promising results in the prevention of neo-ostium restenosis in this proof-of-concept study, indicating that further preclinical and clinical testing may be warranted.
AB - PURPOSE: Ostial restenosis is a common cause of failures in paranasal sinus surgery. The aim of the current study was to investigate the use of low-dose-rate brachytherapy to prevent neo-ostial restenosis in an animal model.METHODS AND MATERIALS: In 14 rabbits, maxillary neo-ostia were created and measured. One side each was stented with a regular silicone stent, the other side was either not stented (n = 7) or stented with a phosphorous-32 implanted stent depositing a low-dose radiation of 15 Gy (n = 7) within 1 week, after which all stents were removed. After a period of additional 12 weeks of recovery, the animals were sacrificed, the neo-ostia were again measured, and the areas and histopathologic changes compared in between the groups.RESULTS: After 15-Gy stenting, the mean ostial areas were even slightly enlarged by 5.1% compared to the area at stent removal, whereas a significant reduction in area, indicating a process of restenosis, by 56.1% or 54.0% was seen in the control groups with no stent and normal stent, respectively. Furthermore, no indication for adverse histopathologic radiation effects was seen in the 15-Gy group.CONCLUSIONS: Low-dose-rate brachytherapy with phosphorous-32 doped silicone stents showed promising results in the prevention of neo-ostium restenosis in this proof-of-concept study, indicating that further preclinical and clinical testing may be warranted.
KW - Animals
KW - Brachytherapy
KW - Constriction, Pathologic
KW - Maxillary Sinus
KW - Paranasal Sinus Diseases
KW - Phosphorus Radioisotopes
KW - Postoperative Complications
KW - Rabbits
KW - Stents
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.brachy.2016.08.011
DO - 10.1016/j.brachy.2016.08.011
M3 - SCORING: Journal article
C2 - 27693170
VL - 16
SP - 207
EP - 214
JO - BRACHYTHERAPY
JF - BRACHYTHERAPY
SN - 1538-4721
IS - 1
ER -