Pränatale, geschlechtsspezifische Programmierung und chronische Erkrankungen oder Finis Ab Orígine Pendet
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Pränatale, geschlechtsspezifische Programmierung und chronische Erkrankungen oder Finis Ab Orígine Pendet. / Arck, P C; Hecher, K.
In: BUNDESGESUNDHEITSBLA, Vol. 57, No. 9, 01.09.2014, p. 1061-6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Pränatale, geschlechtsspezifische Programmierung und chronische Erkrankungen oder Finis Ab Orígine Pendet
AU - Arck, P C
AU - Hecher, K
PY - 2014/9/1
Y1 - 2014/9/1
N2 - An increasing incidence of chronic immune diseases such as allergies, multiple sclerosis, and type 2 diabetes, as well as obesity and cardiovascular and psychiatric disorders has been reported over the last five decades. Since the human genome has not altered significantly over this period of time, gene-environment interactions are suspected to be responsible for these increased disease incidences. In this context, the prenatal period is believed to significantly contribute to altered disease susceptibilities, which could be associated with environmental factors to which pregnant women were exposed to. This observation has led to a concept entitled 'developmental origin of health and disease', a topic that is enjoying much attention in clinical and basic science research. The aim of these research endeavors is to postulate guidelines for primary disease prevention. Whilst the emerging insights from this field of research provide significant pieces of the puzzle, one area is still largely neglected: the clear identification of a sex-specific programming effect. Thus it is essential that such an approach becomes fully integrated in future research goals.
AB - An increasing incidence of chronic immune diseases such as allergies, multiple sclerosis, and type 2 diabetes, as well as obesity and cardiovascular and psychiatric disorders has been reported over the last five decades. Since the human genome has not altered significantly over this period of time, gene-environment interactions are suspected to be responsible for these increased disease incidences. In this context, the prenatal period is believed to significantly contribute to altered disease susceptibilities, which could be associated with environmental factors to which pregnant women were exposed to. This observation has led to a concept entitled 'developmental origin of health and disease', a topic that is enjoying much attention in clinical and basic science research. The aim of these research endeavors is to postulate guidelines for primary disease prevention. Whilst the emerging insights from this field of research provide significant pieces of the puzzle, one area is still largely neglected: the clear identification of a sex-specific programming effect. Thus it is essential that such an approach becomes fully integrated in future research goals.
KW - Chronic Disease
KW - Embryonic Development
KW - Epigenesis, Genetic
KW - Female
KW - Gene-Environment Interaction
KW - Genetic Predisposition to Disease
KW - Humans
KW - Male
KW - Models, Genetic
KW - Sex Characteristics
KW - Sex Factors
U2 - 10.1007/s00103-014-2015-3
DO - 10.1007/s00103-014-2015-3
M3 - SCORING: Zeitschriftenaufsatz
C2 - 25098902
VL - 57
SP - 1061
EP - 1066
JO - BUNDESGESUNDHEITSBLA
JF - BUNDESGESUNDHEITSBLA
SN - 1436-9990
IS - 9
ER -