Pränatale, geschlechtsspezifische Programmierung und chronische Erkrankungen oder Finis Ab Orígine Pendet

TY - JOUR

T1 - Pränatale, geschlechtsspezifische Programmierung und chronische Erkrankungen oder Finis Ab Orígine Pendet

AU - Arck, P C

AU - Hecher, K

PY - 2014/9/1

Y1 - 2014/9/1

N2 - An increasing incidence of chronic immune diseases such as allergies, multiple sclerosis, and type 2 diabetes, as well as obesity and cardiovascular and psychiatric disorders has been reported over the last five decades. Since the human genome has not altered significantly over this period of time, gene-environment interactions are suspected to be responsible for these increased disease incidences. In this context, the prenatal period is believed to significantly contribute to altered disease susceptibilities, which could be associated with environmental factors to which pregnant women were exposed to. This observation has led to a concept entitled 'developmental origin of health and disease', a topic that is enjoying much attention in clinical and basic science research. The aim of these research endeavors is to postulate guidelines for primary disease prevention. Whilst the emerging insights from this field of research provide significant pieces of the puzzle, one area is still largely neglected: the clear identification of a sex-specific programming effect. Thus it is essential that such an approach becomes fully integrated in future research goals.

AB - An increasing incidence of chronic immune diseases such as allergies, multiple sclerosis, and type 2 diabetes, as well as obesity and cardiovascular and psychiatric disorders has been reported over the last five decades. Since the human genome has not altered significantly over this period of time, gene-environment interactions are suspected to be responsible for these increased disease incidences. In this context, the prenatal period is believed to significantly contribute to altered disease susceptibilities, which could be associated with environmental factors to which pregnant women were exposed to. This observation has led to a concept entitled 'developmental origin of health and disease', a topic that is enjoying much attention in clinical and basic science research. The aim of these research endeavors is to postulate guidelines for primary disease prevention. Whilst the emerging insights from this field of research provide significant pieces of the puzzle, one area is still largely neglected: the clear identification of a sex-specific programming effect. Thus it is essential that such an approach becomes fully integrated in future research goals.

KW - Chronic Disease

KW - Embryonic Development

KW - Epigenesis, Genetic

KW - Female

KW - Gene-Environment Interaction

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Models, Genetic

KW - Sex Characteristics

KW - Sex Factors

U2 - 10.1007/s00103-014-2015-3

DO - 10.1007/s00103-014-2015-3

M3 - SCORING: Zeitschriftenaufsatz

C2 - 25098902

VL - 57

SP - 1061

EP - 1066

JO - BUNDESGESUNDHEITSBLA

JF - BUNDESGESUNDHEITSBLA

SN - 1436-9990

IS - 9

ER -