Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation

Matthias Kneussel; Torben Johann Hausrat

doi:10.1016/j.tins.2016.01.002

Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation

Standard

Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation. / Kneussel, Matthias ; Hausrat, Torben Johann.

In: TRENDS NEUROSCI, Vol. 39, No. 3, 03.2016, p. 170-82.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kneussel, M & Hausrat, TJ 2016, 'Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation', TRENDS NEUROSCI, vol. 39, no. 3, pp. 170-82. https://doi.org/10.1016/j.tins.2016.01.002

APA

Kneussel, M., & Hausrat, T. J. (2016). Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation. TRENDS NEUROSCI, 39(3), 170-82. https://doi.org/10.1016/j.tins.2016.01.002

Vancouver

Kneussel M , Hausrat TJ. Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation. TRENDS NEUROSCI. 2016 Mar;39(3):170-82. https://doi.org/10.1016/j.tins.2016.01.002

Bibtex

@article{3f8361a4b58e40f586ec716545579bce,

title = "Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation",

abstract = "At excitatory and inhibitory synapses, an immediate transfer of additional neurotransmitter receptors from non-synaptic positions to the synapse mediates synaptic long-term potentiation (LTP). Different types of non-synaptic reserve pools permit the rapid supply of transmembrane neurotransmitter receptors. Recycling endosomes (REs) serve as an intracellular reservoir of receptors that is delivered to the plasma membrane on LTP induction. Furthermore, AMPA receptors at the non-synaptic plasma membrane provide an extrasynaptic reserve pool that is also important to potentiate synapse function. Finally, bidirectional synaptic versus extrasynaptic trapping of freely diffusing plasma membrane GABAA receptors (GABAARs) by scaffolding proteins modulates synaptic transmission. Here we discuss novel findings regarding neurotransmitter receptor reservoirs and potential reserve pool mechanisms for synaptic potentiation.",

author = "Matthias Kneussel and Hausrat, {Torben Johann}",

year = "2016",

month = mar,

doi = "10.1016/j.tins.2016.01.002",

language = "English",

volume = "39",

pages = "170--82",

journal = "TRENDS NEUROSCI",

issn = "0166-2236",

publisher = "Elsevier Limited",

number = "3",

}

RIS

TY - JOUR

T1 - Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation

AU - Kneussel, Matthias

AU - Hausrat, Torben Johann

PY - 2016/3

Y1 - 2016/3

N2 - At excitatory and inhibitory synapses, an immediate transfer of additional neurotransmitter receptors from non-synaptic positions to the synapse mediates synaptic long-term potentiation (LTP). Different types of non-synaptic reserve pools permit the rapid supply of transmembrane neurotransmitter receptors. Recycling endosomes (REs) serve as an intracellular reservoir of receptors that is delivered to the plasma membrane on LTP induction. Furthermore, AMPA receptors at the non-synaptic plasma membrane provide an extrasynaptic reserve pool that is also important to potentiate synapse function. Finally, bidirectional synaptic versus extrasynaptic trapping of freely diffusing plasma membrane GABAA receptors (GABAARs) by scaffolding proteins modulates synaptic transmission. Here we discuss novel findings regarding neurotransmitter receptor reservoirs and potential reserve pool mechanisms for synaptic potentiation.

AB - At excitatory and inhibitory synapses, an immediate transfer of additional neurotransmitter receptors from non-synaptic positions to the synapse mediates synaptic long-term potentiation (LTP). Different types of non-synaptic reserve pools permit the rapid supply of transmembrane neurotransmitter receptors. Recycling endosomes (REs) serve as an intracellular reservoir of receptors that is delivered to the plasma membrane on LTP induction. Furthermore, AMPA receptors at the non-synaptic plasma membrane provide an extrasynaptic reserve pool that is also important to potentiate synapse function. Finally, bidirectional synaptic versus extrasynaptic trapping of freely diffusing plasma membrane GABAA receptors (GABAARs) by scaffolding proteins modulates synaptic transmission. Here we discuss novel findings regarding neurotransmitter receptor reservoirs and potential reserve pool mechanisms for synaptic potentiation.

U2 - 10.1016/j.tins.2016.01.002

DO - 10.1016/j.tins.2016.01.002

M3 - SCORING: Journal article

C2 - 26833258

VL - 39

SP - 170

EP - 182

JO - TRENDS NEUROSCI

JF - TRENDS NEUROSCI

SN - 0166-2236

IS - 3

ER -