Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation
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Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation. / Kneussel, Matthias; Hausrat, Torben Johann.
in: TRENDS NEUROSCI, Jahrgang 39, Nr. 3, 03.2016, S. 170-82.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation
AU - Kneussel, Matthias
AU - Hausrat, Torben Johann
N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.
PY - 2016/3
Y1 - 2016/3
N2 - At excitatory and inhibitory synapses, an immediate transfer of additional neurotransmitter receptors from non-synaptic positions to the synapse mediates synaptic long-term potentiation (LTP). Different types of non-synaptic reserve pools permit the rapid supply of transmembrane neurotransmitter receptors. Recycling endosomes (REs) serve as an intracellular reservoir of receptors that is delivered to the plasma membrane on LTP induction. Furthermore, AMPA receptors at the non-synaptic plasma membrane provide an extrasynaptic reserve pool that is also important to potentiate synapse function. Finally, bidirectional synaptic versus extrasynaptic trapping of freely diffusing plasma membrane GABAA receptors (GABAARs) by scaffolding proteins modulates synaptic transmission. Here we discuss novel findings regarding neurotransmitter receptor reservoirs and potential reserve pool mechanisms for synaptic potentiation.
AB - At excitatory and inhibitory synapses, an immediate transfer of additional neurotransmitter receptors from non-synaptic positions to the synapse mediates synaptic long-term potentiation (LTP). Different types of non-synaptic reserve pools permit the rapid supply of transmembrane neurotransmitter receptors. Recycling endosomes (REs) serve as an intracellular reservoir of receptors that is delivered to the plasma membrane on LTP induction. Furthermore, AMPA receptors at the non-synaptic plasma membrane provide an extrasynaptic reserve pool that is also important to potentiate synapse function. Finally, bidirectional synaptic versus extrasynaptic trapping of freely diffusing plasma membrane GABAA receptors (GABAARs) by scaffolding proteins modulates synaptic transmission. Here we discuss novel findings regarding neurotransmitter receptor reservoirs and potential reserve pool mechanisms for synaptic potentiation.
U2 - 10.1016/j.tins.2016.01.002
DO - 10.1016/j.tins.2016.01.002
M3 - SCORING: Journal article
C2 - 26833258
VL - 39
SP - 170
EP - 182
JO - TRENDS NEUROSCI
JF - TRENDS NEUROSCI
SN - 0166-2236
IS - 3
ER -