Post-mortem histopathology of pituitary and adrenals of COVID-19 patients

Antonia Fitzek; Moritz Gerling; Klaus Püschel; Wolfgang Saeger

doi:10.1016/j.legalmed.2022.102045

Post-mortem histopathology of pituitary and adrenals of COVID-19 patients

Standard

Post-mortem histopathology of pituitary and adrenals of COVID-19 patients. / Fitzek, Antonia ; Gerling, Moritz ; Püschel, Klaus; Saeger, Wolfgang.

In: LEGAL MED-TOKYO, Vol. 57, 102045, 07.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fitzek, A , Gerling, M , Püschel, K & Saeger, W 2022, 'Post-mortem histopathology of pituitary and adrenals of COVID-19 patients', LEGAL MED-TOKYO, vol. 57, 102045. https://doi.org/10.1016/j.legalmed.2022.102045

APA

Fitzek, A., Gerling, M., Püschel, K., & Saeger, W. (2022). Post-mortem histopathology of pituitary and adrenals of COVID-19 patients. LEGAL MED-TOKYO, 57, [102045]. https://doi.org/10.1016/j.legalmed.2022.102045

Vancouver

Fitzek A , Gerling M , Püschel K, Saeger W. Post-mortem histopathology of pituitary and adrenals of COVID-19 patients. LEGAL MED-TOKYO. 2022 Jul;57. 102045. https://doi.org/10.1016/j.legalmed.2022.102045

Bibtex

@article{c916c8810cd74f9e8f829ad871009305,

title = "Post-mortem histopathology of pituitary and adrenals of COVID-19 patients",

abstract = "BACKGROUND: Knowledge of the exact organ manifestation is essential for a comprehensive understanding of COVID-19 infection. Here, the histopathological changes in the pituitary and adrenal glands were analyzed.METHODS: In this series, the formalin-fixed tissues of 63 pituitary glands and 50 adrenal glands were examined. We performed HE and PAS staining and examined COVID-19 nucleocapsid antibody immunohistochemically in the pituitary glands and adrenals.RESULTS: Histologically, there was no evidence of COVID-19-specific changes in the pituitary and adrenal glands. Large pituitary necrosis may be interpreted as a shock reaction. Independent of infection, we found one T-cell lymphoma, two adenomas, and four Rathke-type cysts in the pituitary glands, and 70% of the adrenal glands showed decreased lipid content and an increase in compact cells as a stress response. In addition, a cortical adenoma in one adrenal gland and small cortical nodules in three adrenal glands were detected independently of COVID-19.CONCLUSION: Pituitary and adrenal glands do not appear histologically predominant in the course of COVID-19.",

keywords = "Adrenal Glands/pathology, Adrenocortical Adenoma/pathology, COVID-19, Humans, Pituitary Gland/pathology",

author = "Antonia Fitzek and Moritz Gerling and Klaus P{\"u}schel and Wolfgang Saeger",

year = "2022",

month = jul,

doi = "10.1016/j.legalmed.2022.102045",

language = "English",

volume = "57",

journal = "LEGAL MED-TOKYO",

issn = "1344-6223",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Post-mortem histopathology of pituitary and adrenals of COVID-19 patients

AU - Fitzek, Antonia

AU - Gerling, Moritz

AU - Püschel, Klaus

AU - Saeger, Wolfgang

PY - 2022/7

Y1 - 2022/7

N2 - BACKGROUND: Knowledge of the exact organ manifestation is essential for a comprehensive understanding of COVID-19 infection. Here, the histopathological changes in the pituitary and adrenal glands were analyzed.METHODS: In this series, the formalin-fixed tissues of 63 pituitary glands and 50 adrenal glands were examined. We performed HE and PAS staining and examined COVID-19 nucleocapsid antibody immunohistochemically in the pituitary glands and adrenals.RESULTS: Histologically, there was no evidence of COVID-19-specific changes in the pituitary and adrenal glands. Large pituitary necrosis may be interpreted as a shock reaction. Independent of infection, we found one T-cell lymphoma, two adenomas, and four Rathke-type cysts in the pituitary glands, and 70% of the adrenal glands showed decreased lipid content and an increase in compact cells as a stress response. In addition, a cortical adenoma in one adrenal gland and small cortical nodules in three adrenal glands were detected independently of COVID-19.CONCLUSION: Pituitary and adrenal glands do not appear histologically predominant in the course of COVID-19.

AB - BACKGROUND: Knowledge of the exact organ manifestation is essential for a comprehensive understanding of COVID-19 infection. Here, the histopathological changes in the pituitary and adrenal glands were analyzed.METHODS: In this series, the formalin-fixed tissues of 63 pituitary glands and 50 adrenal glands were examined. We performed HE and PAS staining and examined COVID-19 nucleocapsid antibody immunohistochemically in the pituitary glands and adrenals.RESULTS: Histologically, there was no evidence of COVID-19-specific changes in the pituitary and adrenal glands. Large pituitary necrosis may be interpreted as a shock reaction. Independent of infection, we found one T-cell lymphoma, two adenomas, and four Rathke-type cysts in the pituitary glands, and 70% of the adrenal glands showed decreased lipid content and an increase in compact cells as a stress response. In addition, a cortical adenoma in one adrenal gland and small cortical nodules in three adrenal glands were detected independently of COVID-19.CONCLUSION: Pituitary and adrenal glands do not appear histologically predominant in the course of COVID-19.

KW - Adrenal Glands/pathology

KW - Adrenocortical Adenoma/pathology

KW - COVID-19

KW - Humans

KW - Pituitary Gland/pathology

U2 - 10.1016/j.legalmed.2022.102045

DO - 10.1016/j.legalmed.2022.102045

M3 - SCORING: Journal article

C2 - 35334433

VL - 57

JO - LEGAL MED-TOKYO

JF - LEGAL MED-TOKYO

SN - 1344-6223

M1 - 102045

ER -