Post-mortem histopathology of pituitary and adrenals of COVID-19 patients
Related Research units
Abstract
BACKGROUND: Knowledge of the exact organ manifestation is essential for a comprehensive understanding of COVID-19 infection. Here, the histopathological changes in the pituitary and adrenal glands were analyzed.
METHODS: In this series, the formalin-fixed tissues of 63 pituitary glands and 50 adrenal glands were examined. We performed HE and PAS staining and examined COVID-19 nucleocapsid antibody immunohistochemically in the pituitary glands and adrenals.
RESULTS: Histologically, there was no evidence of COVID-19-specific changes in the pituitary and adrenal glands. Large pituitary necrosis may be interpreted as a shock reaction. Independent of infection, we found one T-cell lymphoma, two adenomas, and four Rathke-type cysts in the pituitary glands, and 70% of the adrenal glands showed decreased lipid content and an increase in compact cells as a stress response. In addition, a cortical adenoma in one adrenal gland and small cortical nodules in three adrenal glands were detected independently of COVID-19.
CONCLUSION: Pituitary and adrenal glands do not appear histologically predominant in the course of COVID-19.
Bibliographical data
Original language | English |
---|---|
Article number | 102045 |
ISSN | 1344-6223 |
DOIs | |
Publication status | Published - 07.2022 |
Comment Deanary
Copyright © 2022 Elsevier B.V. All rights reserved.
PubMed | 35334433 |
---|