Post mortem tryptase: A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis

Jack Garland; Benjamin Ondruschka; Ugo Da Broi; Cristian Palmiere; Rexson Tse

doi:10.1016/j.forsciint.2020.110415

Post mortem tryptase

Standard

Post mortem tryptase : A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis. / Garland, Jack; Ondruschka, Benjamin; Da Broi, Ugo; Palmiere, Cristian; Tse, Rexson.

In: FORENSIC SCI INT, Vol. 314, 09.2020, p. 110415.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Garland, J, Ondruschka, B, Da Broi, U, Palmiere, C & Tse, R 2020, 'Post mortem tryptase: A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis', FORENSIC SCI INT, vol. 314, pp. 110415. https://doi.org/10.1016/j.forsciint.2020.110415

APA

Garland, J., Ondruschka, B., Da Broi, U., Palmiere, C., & Tse, R. (2020). Post mortem tryptase: A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis. FORENSIC SCI INT, 314, 110415. https://doi.org/10.1016/j.forsciint.2020.110415

Vancouver

Garland J, Ondruschka B, Da Broi U, Palmiere C, Tse R. Post mortem tryptase: A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis. FORENSIC SCI INT. 2020 Sep;314:110415. https://doi.org/10.1016/j.forsciint.2020.110415

Bibtex

@article{5547623a346246c9a764771645da8ef7,

title = "Post mortem tryptase: A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis",

abstract = "Post mortem tryptase is a commonly-used ancillary test in the investigation of possible anaphylactic deaths. Ante mortem tryptase interpretation differs from post mortem interpretation due to differing priorities, biochemical behaviours and capacity for follow-up. Additionally, post mortem tryptase sampling site, method and even cut-off levels are not standardised between facilities. This review of the literature investigates the existing research and recommendations on the use of post mortem tryptase in suspected anaphylactic deaths. Currently, autopsy recommendations suggest early sampling, standardised sampling technique with clamping of and aspiration from the femoral vein, and for the results to be interpreted within the wider autopsy and clinical context. Areas in need of further research include the effects of cytolysis on tryptase levels and studies to stratify differing tryptase levels based on type of death and anaphylactic trigger.",

author = "Jack Garland and Benjamin Ondruschka and {Da Broi}, Ugo and Cristian Palmiere and Rexson Tse",

year = "2020",

month = sep,

doi = "10.1016/j.forsciint.2020.110415",

language = "English",

volume = "314",

pages = "110415",

journal = "FORENSIC SCI INT",

issn = "0379-0738",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Post mortem tryptase

T2 - A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis

AU - Garland, Jack

AU - Ondruschka, Benjamin

AU - Da Broi, Ugo

AU - Palmiere, Cristian

AU - Tse, Rexson

PY - 2020/9

Y1 - 2020/9

N2 - Post mortem tryptase is a commonly-used ancillary test in the investigation of possible anaphylactic deaths. Ante mortem tryptase interpretation differs from post mortem interpretation due to differing priorities, biochemical behaviours and capacity for follow-up. Additionally, post mortem tryptase sampling site, method and even cut-off levels are not standardised between facilities. This review of the literature investigates the existing research and recommendations on the use of post mortem tryptase in suspected anaphylactic deaths. Currently, autopsy recommendations suggest early sampling, standardised sampling technique with clamping of and aspiration from the femoral vein, and for the results to be interpreted within the wider autopsy and clinical context. Areas in need of further research include the effects of cytolysis on tryptase levels and studies to stratify differing tryptase levels based on type of death and anaphylactic trigger.

AB - Post mortem tryptase is a commonly-used ancillary test in the investigation of possible anaphylactic deaths. Ante mortem tryptase interpretation differs from post mortem interpretation due to differing priorities, biochemical behaviours and capacity for follow-up. Additionally, post mortem tryptase sampling site, method and even cut-off levels are not standardised between facilities. This review of the literature investigates the existing research and recommendations on the use of post mortem tryptase in suspected anaphylactic deaths. Currently, autopsy recommendations suggest early sampling, standardised sampling technique with clamping of and aspiration from the femoral vein, and for the results to be interpreted within the wider autopsy and clinical context. Areas in need of further research include the effects of cytolysis on tryptase levels and studies to stratify differing tryptase levels based on type of death and anaphylactic trigger.

U2 - 10.1016/j.forsciint.2020.110415

DO - 10.1016/j.forsciint.2020.110415

M3 - SCORING: Review article

C2 - 32717658

VL - 314

SP - 110415

JO - FORENSIC SCI INT

JF - FORENSIC SCI INT

SN - 0379-0738

ER -