Post mortem tryptase
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Post mortem tryptase : A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis. / Garland, Jack; Ondruschka, Benjamin; Da Broi, Ugo; Palmiere, Cristian; Tse, Rexson.
in: FORENSIC SCI INT, Jahrgang 314, 09.2020, S. 110415.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Post mortem tryptase
T2 - A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis
AU - Garland, Jack
AU - Ondruschka, Benjamin
AU - Da Broi, Ugo
AU - Palmiere, Cristian
AU - Tse, Rexson
N1 - Copyright © 2020 Elsevier B.V. All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - Post mortem tryptase is a commonly-used ancillary test in the investigation of possible anaphylactic deaths. Ante mortem tryptase interpretation differs from post mortem interpretation due to differing priorities, biochemical behaviours and capacity for follow-up. Additionally, post mortem tryptase sampling site, method and even cut-off levels are not standardised between facilities. This review of the literature investigates the existing research and recommendations on the use of post mortem tryptase in suspected anaphylactic deaths. Currently, autopsy recommendations suggest early sampling, standardised sampling technique with clamping of and aspiration from the femoral vein, and for the results to be interpreted within the wider autopsy and clinical context. Areas in need of further research include the effects of cytolysis on tryptase levels and studies to stratify differing tryptase levels based on type of death and anaphylactic trigger.
AB - Post mortem tryptase is a commonly-used ancillary test in the investigation of possible anaphylactic deaths. Ante mortem tryptase interpretation differs from post mortem interpretation due to differing priorities, biochemical behaviours and capacity for follow-up. Additionally, post mortem tryptase sampling site, method and even cut-off levels are not standardised between facilities. This review of the literature investigates the existing research and recommendations on the use of post mortem tryptase in suspected anaphylactic deaths. Currently, autopsy recommendations suggest early sampling, standardised sampling technique with clamping of and aspiration from the femoral vein, and for the results to be interpreted within the wider autopsy and clinical context. Areas in need of further research include the effects of cytolysis on tryptase levels and studies to stratify differing tryptase levels based on type of death and anaphylactic trigger.
U2 - 10.1016/j.forsciint.2020.110415
DO - 10.1016/j.forsciint.2020.110415
M3 - SCORING: Review article
C2 - 32717658
VL - 314
SP - 110415
JO - FORENSIC SCI INT
JF - FORENSIC SCI INT
SN - 0379-0738
ER -