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Pores of the internal limiting membrane: A common finding in vitreo-maculopathies

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Pores of the internal limiting membrane: A common finding in vitreo-maculopathies. / Schumann, Ricarda Gisela ; Banyai, Daniel; Hagenau, Felix; Mautone, Luca; Thomas, Hammer; Wolf, Armin; Priglinger, Siegfried; Vogt, Denise.

In: RETINA-J RET VIT DIS, Vol. 43, No. 10, 01.10.2023, p. 1773-1779.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schumann, RG, Banyai, D, Hagenau, F, Mautone, L, Thomas, H, Wolf, A, Priglinger, S & Vogt, D 2023, 'Pores of the internal limiting membrane: A common finding in vitreo-maculopathies', RETINA-J RET VIT DIS, vol. 43, no. 10, pp. 1773-1779. https://doi.org/10.1097/IAE.0000000000003859

APA

Schumann, R. G., Banyai, D., Hagenau, F., Mautone, L., Thomas, H., Wolf, A., Priglinger, S., & Vogt, D. (2023). Pores of the internal limiting membrane: A common finding in vitreo-maculopathies. RETINA-J RET VIT DIS, 43(10), 1773-1779. https://doi.org/10.1097/IAE.0000000000003859

Vancouver

Schumann RG, Banyai D, Hagenau F, Mautone L, Thomas H, Wolf A et al. Pores of the internal limiting membrane: A common finding in vitreo-maculopathies. RETINA-J RET VIT DIS. 2023 Oct 1;43(10):1773-1779. https://doi.org/10.1097/IAE.0000000000003859

Bibtex

@article{b3f5cbbae9b745328de095c651e09a1b,
title = "Pores of the internal limiting membrane: A common finding in vitreo-maculopathies",
abstract = "PURPOSE: To describe presence and distribution of pores of the inner limiting membrane (ILM) in eyes with vitreomaculopathies.METHODS: Inner limiting membrane specimens were harvested from 117 eyes of 117 patients during vitrectomy with membrane peeling from eyes with vitreomacular traction syndrome, idiopathic and secondary epiretinal gliosis, and idiopathic full-thickness macular hole. All specimens were processed as flat-mounts for immunocytochemistry and examined by phase-contrast, interference, and fluorescence microscopy. Demographic and clinical data were correlated.RESULTS: Inner limiting membrane pores were found in all vitreomaculopathies. They were identified in 47 (40.2%) of 117 eyes being most evident with antilaminin. In eyes with full-thickness macular hole >400 µ m, pores were seen in more than half of all eyes. They occur as numerous and uniformly distributed defects of the flat-mounted ILM with a mean diameter of 9.5 ± 2.4 µ m. Edges of ILM pores are round with an irregular contour and no specific cellular pattern. Pores were distinguished from retinal vessel thinning and iatrogenic artefacts.CONCLUSION: Contrary to previous reports, ILM pores are a common finding in vitreomaculopathies easily visible with antilaminin staining. Further studies are needed to clarify whether their presence correlates with differences in disease progression or imaging before and after vitrectomy with ILM peeling.",
keywords = "Basement Membrane/surgery, Epiretinal Membrane/diagnosis, Humans, Retina, Retinal Degeneration/surgery, Retinal Perforations/diagnosis, Retrospective Studies, Staining and Labeling, Tomography, Optical Coherence, Vitrectomy/methods",
author = "Schumann, {Ricarda Gisela} and Daniel Banyai and Felix Hagenau and Luca Mautone and Hammer Thomas and Armin Wolf and Siegfried Priglinger and Denise Vogt",
year = "2023",
month = oct,
day = "1",
doi = "10.1097/IAE.0000000000003859",
language = "English",
volume = "43",
pages = "1773--1779",
journal = "RETINA-J RET VIT DIS",
issn = "0275-004X",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

RIS

TY - JOUR

T1 - Pores of the internal limiting membrane: A common finding in vitreo-maculopathies

AU - Schumann, Ricarda Gisela

AU - Banyai, Daniel

AU - Hagenau, Felix

AU - Mautone, Luca

AU - Thomas, Hammer

AU - Wolf, Armin

AU - Priglinger, Siegfried

AU - Vogt, Denise

PY - 2023/10/1

Y1 - 2023/10/1

N2 - PURPOSE: To describe presence and distribution of pores of the inner limiting membrane (ILM) in eyes with vitreomaculopathies.METHODS: Inner limiting membrane specimens were harvested from 117 eyes of 117 patients during vitrectomy with membrane peeling from eyes with vitreomacular traction syndrome, idiopathic and secondary epiretinal gliosis, and idiopathic full-thickness macular hole. All specimens were processed as flat-mounts for immunocytochemistry and examined by phase-contrast, interference, and fluorescence microscopy. Demographic and clinical data were correlated.RESULTS: Inner limiting membrane pores were found in all vitreomaculopathies. They were identified in 47 (40.2%) of 117 eyes being most evident with antilaminin. In eyes with full-thickness macular hole >400 µ m, pores were seen in more than half of all eyes. They occur as numerous and uniformly distributed defects of the flat-mounted ILM with a mean diameter of 9.5 ± 2.4 µ m. Edges of ILM pores are round with an irregular contour and no specific cellular pattern. Pores were distinguished from retinal vessel thinning and iatrogenic artefacts.CONCLUSION: Contrary to previous reports, ILM pores are a common finding in vitreomaculopathies easily visible with antilaminin staining. Further studies are needed to clarify whether their presence correlates with differences in disease progression or imaging before and after vitrectomy with ILM peeling.

AB - PURPOSE: To describe presence and distribution of pores of the inner limiting membrane (ILM) in eyes with vitreomaculopathies.METHODS: Inner limiting membrane specimens were harvested from 117 eyes of 117 patients during vitrectomy with membrane peeling from eyes with vitreomacular traction syndrome, idiopathic and secondary epiretinal gliosis, and idiopathic full-thickness macular hole. All specimens were processed as flat-mounts for immunocytochemistry and examined by phase-contrast, interference, and fluorescence microscopy. Demographic and clinical data were correlated.RESULTS: Inner limiting membrane pores were found in all vitreomaculopathies. They were identified in 47 (40.2%) of 117 eyes being most evident with antilaminin. In eyes with full-thickness macular hole >400 µ m, pores were seen in more than half of all eyes. They occur as numerous and uniformly distributed defects of the flat-mounted ILM with a mean diameter of 9.5 ± 2.4 µ m. Edges of ILM pores are round with an irregular contour and no specific cellular pattern. Pores were distinguished from retinal vessel thinning and iatrogenic artefacts.CONCLUSION: Contrary to previous reports, ILM pores are a common finding in vitreomaculopathies easily visible with antilaminin staining. Further studies are needed to clarify whether their presence correlates with differences in disease progression or imaging before and after vitrectomy with ILM peeling.

KW - Basement Membrane/surgery

KW - Epiretinal Membrane/diagnosis

KW - Humans

KW - Retina

KW - Retinal Degeneration/surgery

KW - Retinal Perforations/diagnosis

KW - Retrospective Studies

KW - Staining and Labeling

KW - Tomography, Optical Coherence

KW - Vitrectomy/methods

U2 - 10.1097/IAE.0000000000003859

DO - 10.1097/IAE.0000000000003859

M3 - SCORING: Journal article

C2 - 37315515

VL - 43

SP - 1773

EP - 1779

JO - RETINA-J RET VIT DIS

JF - RETINA-J RET VIT DIS

SN - 0275-004X

IS - 10

ER -