Pores of the internal limiting membrane: A common finding in vitreo-maculopathies
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Pores of the internal limiting membrane: A common finding in vitreo-maculopathies. / Schumann, Ricarda Gisela ; Banyai, Daniel; Hagenau, Felix; Mautone, Luca; Thomas, Hammer; Wolf, Armin; Priglinger, Siegfried; Vogt, Denise.
in: RETINA-J RET VIT DIS, Jahrgang 43, Nr. 10, 01.10.2023, S. 1773-1779.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Pores of the internal limiting membrane: A common finding in vitreo-maculopathies
AU - Schumann, Ricarda Gisela
AU - Banyai, Daniel
AU - Hagenau, Felix
AU - Mautone, Luca
AU - Thomas, Hammer
AU - Wolf, Armin
AU - Priglinger, Siegfried
AU - Vogt, Denise
PY - 2023/10/1
Y1 - 2023/10/1
N2 - PURPOSE: To describe presence and distribution of pores of the inner limiting membrane (ILM) in eyes with vitreomaculopathies.METHODS: Inner limiting membrane specimens were harvested from 117 eyes of 117 patients during vitrectomy with membrane peeling from eyes with vitreomacular traction syndrome, idiopathic and secondary epiretinal gliosis, and idiopathic full-thickness macular hole. All specimens were processed as flat-mounts for immunocytochemistry and examined by phase-contrast, interference, and fluorescence microscopy. Demographic and clinical data were correlated.RESULTS: Inner limiting membrane pores were found in all vitreomaculopathies. They were identified in 47 (40.2%) of 117 eyes being most evident with antilaminin. In eyes with full-thickness macular hole >400 µ m, pores were seen in more than half of all eyes. They occur as numerous and uniformly distributed defects of the flat-mounted ILM with a mean diameter of 9.5 ± 2.4 µ m. Edges of ILM pores are round with an irregular contour and no specific cellular pattern. Pores were distinguished from retinal vessel thinning and iatrogenic artefacts.CONCLUSION: Contrary to previous reports, ILM pores are a common finding in vitreomaculopathies easily visible with antilaminin staining. Further studies are needed to clarify whether their presence correlates with differences in disease progression or imaging before and after vitrectomy with ILM peeling.
AB - PURPOSE: To describe presence and distribution of pores of the inner limiting membrane (ILM) in eyes with vitreomaculopathies.METHODS: Inner limiting membrane specimens were harvested from 117 eyes of 117 patients during vitrectomy with membrane peeling from eyes with vitreomacular traction syndrome, idiopathic and secondary epiretinal gliosis, and idiopathic full-thickness macular hole. All specimens were processed as flat-mounts for immunocytochemistry and examined by phase-contrast, interference, and fluorescence microscopy. Demographic and clinical data were correlated.RESULTS: Inner limiting membrane pores were found in all vitreomaculopathies. They were identified in 47 (40.2%) of 117 eyes being most evident with antilaminin. In eyes with full-thickness macular hole >400 µ m, pores were seen in more than half of all eyes. They occur as numerous and uniformly distributed defects of the flat-mounted ILM with a mean diameter of 9.5 ± 2.4 µ m. Edges of ILM pores are round with an irregular contour and no specific cellular pattern. Pores were distinguished from retinal vessel thinning and iatrogenic artefacts.CONCLUSION: Contrary to previous reports, ILM pores are a common finding in vitreomaculopathies easily visible with antilaminin staining. Further studies are needed to clarify whether their presence correlates with differences in disease progression or imaging before and after vitrectomy with ILM peeling.
KW - Basement Membrane/surgery
KW - Epiretinal Membrane/diagnosis
KW - Humans
KW - Retina
KW - Retinal Degeneration/surgery
KW - Retinal Perforations/diagnosis
KW - Retrospective Studies
KW - Staining and Labeling
KW - Tomography, Optical Coherence
KW - Vitrectomy/methods
U2 - 10.1097/IAE.0000000000003859
DO - 10.1097/IAE.0000000000003859
M3 - SCORING: Journal article
C2 - 37315515
VL - 43
SP - 1773
EP - 1779
JO - RETINA-J RET VIT DIS
JF - RETINA-J RET VIT DIS
SN - 0275-004X
IS - 10
ER -