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Polyphosphate as a Target for Interference With Inflammation and Thrombosis

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Polyphosphate as a Target for Interference With Inflammation and Thrombosis. / Mailer, Reiner K W; Hänel, Lorena; Allende, Mikel; Renné, Thomas.

In: FRONT MED-LAUSANNE, Vol. 6, 2019, p. 76.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Mailer, RKW, Hänel, L, Allende, M & Renné, T 2019, 'Polyphosphate as a Target for Interference With Inflammation and Thrombosis', FRONT MED-LAUSANNE, vol. 6, pp. 76. https://doi.org/10.3389/fmed.2019.00076

APA

Mailer, R. K. W., Hänel, L., Allende, M., & Renné, T. (2019). Polyphosphate as a Target for Interference With Inflammation and Thrombosis. FRONT MED-LAUSANNE, 6, 76. https://doi.org/10.3389/fmed.2019.00076

Vancouver

Mailer RKW, Hänel L, Allende M, Renné T. Polyphosphate as a Target for Interference With Inflammation and Thrombosis. FRONT MED-LAUSANNE. 2019;6:76. https://doi.org/10.3389/fmed.2019.00076

Bibtex

@article{c9c469d3f9cf4f9f86aecd43f20a9385,
title = "Polyphosphate as a Target for Interference With Inflammation and Thrombosis",
abstract = "Activated platelets and mast cells expose the inorganic polymer, polyphosphate (polyP) on their surfaces. PolyP initiates procoagulant and proinflammatory reactions and the polymer has been recognized as a therapeutic target for interference with blood coagulation and vascular hyperpermeability. PolyP content and chain length depend on the specific cell type and energy status, which may affect cellular functions. PolyP metabolism has mainly been studied in bacteria and yeast, but its roles in eukaryotic cells and mammalian systems have remained enigmatic. In this review, we will present an overview of polyP functions, focusing on intra- and extracellular roles of the polymer and discuss open questions that emerge from the current knowledge on polyP regulation.",
author = "Mailer, {Reiner K W} and Lorena H{\"a}nel and Mikel Allende and Thomas Renn{\'e}",
year = "2019",
doi = "10.3389/fmed.2019.00076",
language = "English",
volume = "6",
pages = "76",
journal = "FRONT MED-LAUSANNE",
issn = "2296-858X",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Polyphosphate as a Target for Interference With Inflammation and Thrombosis

AU - Mailer, Reiner K W

AU - Hänel, Lorena

AU - Allende, Mikel

AU - Renné, Thomas

PY - 2019

Y1 - 2019

N2 - Activated platelets and mast cells expose the inorganic polymer, polyphosphate (polyP) on their surfaces. PolyP initiates procoagulant and proinflammatory reactions and the polymer has been recognized as a therapeutic target for interference with blood coagulation and vascular hyperpermeability. PolyP content and chain length depend on the specific cell type and energy status, which may affect cellular functions. PolyP metabolism has mainly been studied in bacteria and yeast, but its roles in eukaryotic cells and mammalian systems have remained enigmatic. In this review, we will present an overview of polyP functions, focusing on intra- and extracellular roles of the polymer and discuss open questions that emerge from the current knowledge on polyP regulation.

AB - Activated platelets and mast cells expose the inorganic polymer, polyphosphate (polyP) on their surfaces. PolyP initiates procoagulant and proinflammatory reactions and the polymer has been recognized as a therapeutic target for interference with blood coagulation and vascular hyperpermeability. PolyP content and chain length depend on the specific cell type and energy status, which may affect cellular functions. PolyP metabolism has mainly been studied in bacteria and yeast, but its roles in eukaryotic cells and mammalian systems have remained enigmatic. In this review, we will present an overview of polyP functions, focusing on intra- and extracellular roles of the polymer and discuss open questions that emerge from the current knowledge on polyP regulation.

U2 - 10.3389/fmed.2019.00076

DO - 10.3389/fmed.2019.00076

M3 - SCORING: Review article

C2 - 31106204

VL - 6

SP - 76

JO - FRONT MED-LAUSANNE

JF - FRONT MED-LAUSANNE

SN - 2296-858X

ER -