Polyphosphate as a Target for Interference With Inflammation and Thrombosis
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Polyphosphate as a Target for Interference With Inflammation and Thrombosis. / Mailer, Reiner K W; Hänel, Lorena; Allende, Mikel; Renné, Thomas.
in: FRONT MED-LAUSANNE, Jahrgang 6, 2019, S. 76.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Polyphosphate as a Target for Interference With Inflammation and Thrombosis
AU - Mailer, Reiner K W
AU - Hänel, Lorena
AU - Allende, Mikel
AU - Renné, Thomas
PY - 2019
Y1 - 2019
N2 - Activated platelets and mast cells expose the inorganic polymer, polyphosphate (polyP) on their surfaces. PolyP initiates procoagulant and proinflammatory reactions and the polymer has been recognized as a therapeutic target for interference with blood coagulation and vascular hyperpermeability. PolyP content and chain length depend on the specific cell type and energy status, which may affect cellular functions. PolyP metabolism has mainly been studied in bacteria and yeast, but its roles in eukaryotic cells and mammalian systems have remained enigmatic. In this review, we will present an overview of polyP functions, focusing on intra- and extracellular roles of the polymer and discuss open questions that emerge from the current knowledge on polyP regulation.
AB - Activated platelets and mast cells expose the inorganic polymer, polyphosphate (polyP) on their surfaces. PolyP initiates procoagulant and proinflammatory reactions and the polymer has been recognized as a therapeutic target for interference with blood coagulation and vascular hyperpermeability. PolyP content and chain length depend on the specific cell type and energy status, which may affect cellular functions. PolyP metabolism has mainly been studied in bacteria and yeast, but its roles in eukaryotic cells and mammalian systems have remained enigmatic. In this review, we will present an overview of polyP functions, focusing on intra- and extracellular roles of the polymer and discuss open questions that emerge from the current knowledge on polyP regulation.
U2 - 10.3389/fmed.2019.00076
DO - 10.3389/fmed.2019.00076
M3 - SCORING: Review article
C2 - 31106204
VL - 6
SP - 76
JO - FRONT MED-LAUSANNE
JF - FRONT MED-LAUSANNE
SN - 2296-858X
ER -