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Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis

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Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis. / Mascher, B; Schmitt, W; Csernok, E; Tatsis, E; Reil, A; Gross, W L; Seyfarth, M.

In: EXP CLIN IMMUNOGENET, Vol. 14, No. 3, 1997, p. 226-33.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mascher, B, Schmitt, W, Csernok, E, Tatsis, E, Reil, A, Gross, WL & Seyfarth, M 1997, 'Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis', EXP CLIN IMMUNOGENET, vol. 14, no. 3, pp. 226-33.

APA

Mascher, B., Schmitt, W., Csernok, E., Tatsis, E., Reil, A., Gross, W. L., & Seyfarth, M. (1997). Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis. EXP CLIN IMMUNOGENET, 14(3), 226-33.

Vancouver

Mascher B, Schmitt W, Csernok E, Tatsis E, Reil A, Gross WL et al. Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis. EXP CLIN IMMUNOGENET. 1997;14(3):226-33.

Bibtex

@article{81933859ed3b49c693f10fa94b9409a8,
title = "Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis",
abstract = "Two known di-allelic polymorphisms in the tumor necrosis factor (TNF) genes were investigated in 35 patients suffering from Wegener's granulomatosis (WG) in comparison to 111 healthy controls. The first polymorphism lay in the promotor region of the TNF-alpha gene at position -308, the second in the first intron of the TNF-beta gene. For both polymorphisms we could not find any statistically significant differences in allele frequencies between patients and healthy individuals. In the patient group the TNF 2/2 phenotype was slightly elevated, however (WG 5.7% vs. normal 1.8%). Investigating the clinical course of the disease according to TNF polymorphisms, TNF 1/1 patients were found to have a higher mean disease extension index (DEI) than TNF 1/2 individuals (TNF 1/1 10.5 vs. TNF 1/2 9.4).",
keywords = "Granulomatosis with Polyangiitis/genetics, Humans, Lymphotoxin-alpha/genetics, Polymorphism, Genetic, Tumor Necrosis Factor-alpha/genetics",
author = "B Mascher and W Schmitt and E Csernok and E Tatsis and A Reil and Gross, {W L} and M Seyfarth",
year = "1997",
language = "English",
volume = "14",
pages = "226--33",
journal = "EXP CLIN IMMUNOGENET",
issn = "0254-9670",
publisher = "S. Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis

AU - Mascher, B

AU - Schmitt, W

AU - Csernok, E

AU - Tatsis, E

AU - Reil, A

AU - Gross, W L

AU - Seyfarth, M

PY - 1997

Y1 - 1997

N2 - Two known di-allelic polymorphisms in the tumor necrosis factor (TNF) genes were investigated in 35 patients suffering from Wegener's granulomatosis (WG) in comparison to 111 healthy controls. The first polymorphism lay in the promotor region of the TNF-alpha gene at position -308, the second in the first intron of the TNF-beta gene. For both polymorphisms we could not find any statistically significant differences in allele frequencies between patients and healthy individuals. In the patient group the TNF 2/2 phenotype was slightly elevated, however (WG 5.7% vs. normal 1.8%). Investigating the clinical course of the disease according to TNF polymorphisms, TNF 1/1 patients were found to have a higher mean disease extension index (DEI) than TNF 1/2 individuals (TNF 1/1 10.5 vs. TNF 1/2 9.4).

AB - Two known di-allelic polymorphisms in the tumor necrosis factor (TNF) genes were investigated in 35 patients suffering from Wegener's granulomatosis (WG) in comparison to 111 healthy controls. The first polymorphism lay in the promotor region of the TNF-alpha gene at position -308, the second in the first intron of the TNF-beta gene. For both polymorphisms we could not find any statistically significant differences in allele frequencies between patients and healthy individuals. In the patient group the TNF 2/2 phenotype was slightly elevated, however (WG 5.7% vs. normal 1.8%). Investigating the clinical course of the disease according to TNF polymorphisms, TNF 1/1 patients were found to have a higher mean disease extension index (DEI) than TNF 1/2 individuals (TNF 1/1 10.5 vs. TNF 1/2 9.4).

KW - Granulomatosis with Polyangiitis/genetics

KW - Humans

KW - Lymphotoxin-alpha/genetics

KW - Polymorphism, Genetic

KW - Tumor Necrosis Factor-alpha/genetics

M3 - SCORING: Journal article

C2 - 9493791

VL - 14

SP - 226

EP - 233

JO - EXP CLIN IMMUNOGENET

JF - EXP CLIN IMMUNOGENET

SN - 0254-9670

IS - 3

ER -