Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis
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Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis. / Mascher, B; Schmitt, W; Csernok, E; Tatsis, E; Reil, A; Gross, W L; Seyfarth, M.
in: EXP CLIN IMMUNOGENET, Jahrgang 14, Nr. 3, 1997, S. 226-33.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Polymorphisms in the tumor necrosis factor genes in Wegener's granulomatosis
AU - Mascher, B
AU - Schmitt, W
AU - Csernok, E
AU - Tatsis, E
AU - Reil, A
AU - Gross, W L
AU - Seyfarth, M
PY - 1997
Y1 - 1997
N2 - Two known di-allelic polymorphisms in the tumor necrosis factor (TNF) genes were investigated in 35 patients suffering from Wegener's granulomatosis (WG) in comparison to 111 healthy controls. The first polymorphism lay in the promotor region of the TNF-alpha gene at position -308, the second in the first intron of the TNF-beta gene. For both polymorphisms we could not find any statistically significant differences in allele frequencies between patients and healthy individuals. In the patient group the TNF 2/2 phenotype was slightly elevated, however (WG 5.7% vs. normal 1.8%). Investigating the clinical course of the disease according to TNF polymorphisms, TNF 1/1 patients were found to have a higher mean disease extension index (DEI) than TNF 1/2 individuals (TNF 1/1 10.5 vs. TNF 1/2 9.4).
AB - Two known di-allelic polymorphisms in the tumor necrosis factor (TNF) genes were investigated in 35 patients suffering from Wegener's granulomatosis (WG) in comparison to 111 healthy controls. The first polymorphism lay in the promotor region of the TNF-alpha gene at position -308, the second in the first intron of the TNF-beta gene. For both polymorphisms we could not find any statistically significant differences in allele frequencies between patients and healthy individuals. In the patient group the TNF 2/2 phenotype was slightly elevated, however (WG 5.7% vs. normal 1.8%). Investigating the clinical course of the disease according to TNF polymorphisms, TNF 1/1 patients were found to have a higher mean disease extension index (DEI) than TNF 1/2 individuals (TNF 1/1 10.5 vs. TNF 1/2 9.4).
KW - Granulomatosis with Polyangiitis/genetics
KW - Humans
KW - Lymphotoxin-alpha/genetics
KW - Polymorphism, Genetic
KW - Tumor Necrosis Factor-alpha/genetics
M3 - SCORING: Journal article
C2 - 9493791
VL - 14
SP - 226
EP - 233
JO - EXP CLIN IMMUNOGENET
JF - EXP CLIN IMMUNOGENET
SN - 0254-9670
IS - 3
ER -