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Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy?

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Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy? / Seibold, Petra; Hall, Per; Schoof, Nils; Nevanlinna, Heli; Heikkinen, Tuomas; Benner, Axel; Liu, Jianjun; Schmezer, Peter; Popanda, Odilia; Flesch-Janys, Dieter; Chang-Claude, Jenny.

In: BREAST, Vol. 22, No. 5, 01.10.2013, p. 817-23.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Seibold, P, Hall, P, Schoof, N, Nevanlinna, H, Heikkinen, T, Benner, A, Liu, J, Schmezer, P, Popanda, O, Flesch-Janys, D & Chang-Claude, J 2013, 'Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy?', BREAST, vol. 22, no. 5, pp. 817-23. https://doi.org/10.1016/j.breast.2013.02.008

APA

Seibold, P., Hall, P., Schoof, N., Nevanlinna, H., Heikkinen, T., Benner, A., Liu, J., Schmezer, P., Popanda, O., Flesch-Janys, D., & Chang-Claude, J. (2013). Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy? BREAST, 22(5), 817-23. https://doi.org/10.1016/j.breast.2013.02.008

Vancouver

Seibold P, Hall P, Schoof N, Nevanlinna H, Heikkinen T, Benner A et al. Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy? BREAST. 2013 Oct 1;22(5):817-23. https://doi.org/10.1016/j.breast.2013.02.008

Bibtex

@article{f469e7e8a9b84eb58b81bcc3e3ac821e,
title = "Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy?",
abstract = "We assessed whether variants in 22 oxidative stress-related genes are associated with mortality of breast cancer patients and whether the associations differ according to radiotherapy. Using a prospective cohort of 1348 postmenopausal breast cancer patients, we estimated hazard ratios (HR) and 95% confidence intervals (CI) for 109 single nucleotide polymorphisms (SNPs) using Cox proportional hazards regression. Validation of results was attempted using two Scandinavian studies. Eleven SNPs in MT2A, NFE2L2, NQO1, PRDX1, and PRDX6 were significantly associated with overall mortality after a median follow-up of 5.7 years. Three SNPs in NQO1 (rs2917667) and in PRDX6 (rs7314, rs4916362) were consistently associated with increased risk of dying across all three study populations (pooled: HRNQO1_rs2917667 1.20, 95% CI 1.00-1.44, p = 0.051; HRPRDX6_rs7314 1.16, 95% CI 1.00-1.35, p = 0.056, HRPRDX6_rs4916362 1.14 95% CI 1.00-1.32, p = 0.062). Potential effect modification by radiotherapy was found for CAT_rs769218. In conclusion, genetic variants in NQO1 and PRDX6 may modify breast cancer prognosis.",
keywords = "Aged, Aged, 80 and over, Breast Neoplasms, Catalase, Female, Genotype, Histone Deacetylases, Humans, Kaplan-Meier Estimate, Middle Aged, NAD(P)H Dehydrogenase (Quinone), NF-E2-Related Factor 2, Oxidative Stress, Peroxiredoxin VI, Peroxiredoxins, Polymorphism, Single Nucleotide, Prognosis, Prospective Studies, Repressor Proteins",
author = "Petra Seibold and Per Hall and Nils Schoof and Heli Nevanlinna and Tuomas Heikkinen and Axel Benner and Jianjun Liu and Peter Schmezer and Odilia Popanda and Dieter Flesch-Janys and Jenny Chang-Claude",
note = "Copyright {\textcopyright} 2013 Elsevier Ltd. All rights reserved.",
year = "2013",
month = oct,
day = "1",
doi = "10.1016/j.breast.2013.02.008",
language = "English",
volume = "22",
pages = "817--23",
journal = "BREAST",
issn = "0960-9776",
publisher = "Churchill Livingstone",
number = "5",

}

RIS

TY - JOUR

T1 - Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy?

AU - Seibold, Petra

AU - Hall, Per

AU - Schoof, Nils

AU - Nevanlinna, Heli

AU - Heikkinen, Tuomas

AU - Benner, Axel

AU - Liu, Jianjun

AU - Schmezer, Peter

AU - Popanda, Odilia

AU - Flesch-Janys, Dieter

AU - Chang-Claude, Jenny

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - We assessed whether variants in 22 oxidative stress-related genes are associated with mortality of breast cancer patients and whether the associations differ according to radiotherapy. Using a prospective cohort of 1348 postmenopausal breast cancer patients, we estimated hazard ratios (HR) and 95% confidence intervals (CI) for 109 single nucleotide polymorphisms (SNPs) using Cox proportional hazards regression. Validation of results was attempted using two Scandinavian studies. Eleven SNPs in MT2A, NFE2L2, NQO1, PRDX1, and PRDX6 were significantly associated with overall mortality after a median follow-up of 5.7 years. Three SNPs in NQO1 (rs2917667) and in PRDX6 (rs7314, rs4916362) were consistently associated with increased risk of dying across all three study populations (pooled: HRNQO1_rs2917667 1.20, 95% CI 1.00-1.44, p = 0.051; HRPRDX6_rs7314 1.16, 95% CI 1.00-1.35, p = 0.056, HRPRDX6_rs4916362 1.14 95% CI 1.00-1.32, p = 0.062). Potential effect modification by radiotherapy was found for CAT_rs769218. In conclusion, genetic variants in NQO1 and PRDX6 may modify breast cancer prognosis.

AB - We assessed whether variants in 22 oxidative stress-related genes are associated with mortality of breast cancer patients and whether the associations differ according to radiotherapy. Using a prospective cohort of 1348 postmenopausal breast cancer patients, we estimated hazard ratios (HR) and 95% confidence intervals (CI) for 109 single nucleotide polymorphisms (SNPs) using Cox proportional hazards regression. Validation of results was attempted using two Scandinavian studies. Eleven SNPs in MT2A, NFE2L2, NQO1, PRDX1, and PRDX6 were significantly associated with overall mortality after a median follow-up of 5.7 years. Three SNPs in NQO1 (rs2917667) and in PRDX6 (rs7314, rs4916362) were consistently associated with increased risk of dying across all three study populations (pooled: HRNQO1_rs2917667 1.20, 95% CI 1.00-1.44, p = 0.051; HRPRDX6_rs7314 1.16, 95% CI 1.00-1.35, p = 0.056, HRPRDX6_rs4916362 1.14 95% CI 1.00-1.32, p = 0.062). Potential effect modification by radiotherapy was found for CAT_rs769218. In conclusion, genetic variants in NQO1 and PRDX6 may modify breast cancer prognosis.

KW - Aged

KW - Aged, 80 and over

KW - Breast Neoplasms

KW - Catalase

KW - Female

KW - Genotype

KW - Histone Deacetylases

KW - Humans

KW - Kaplan-Meier Estimate

KW - Middle Aged

KW - NAD(P)H Dehydrogenase (Quinone)

KW - NF-E2-Related Factor 2

KW - Oxidative Stress

KW - Peroxiredoxin VI

KW - Peroxiredoxins

KW - Polymorphism, Single Nucleotide

KW - Prognosis

KW - Prospective Studies

KW - Repressor Proteins

U2 - 10.1016/j.breast.2013.02.008

DO - 10.1016/j.breast.2013.02.008

M3 - SCORING: Journal article

C2 - 23489758

VL - 22

SP - 817

EP - 823

JO - BREAST

JF - BREAST

SN - 0960-9776

IS - 5

ER -