Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy?
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Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy? / Seibold, Petra; Hall, Per; Schoof, Nils; Nevanlinna, Heli; Heikkinen, Tuomas; Benner, Axel; Liu, Jianjun; Schmezer, Peter; Popanda, Odilia; Flesch-Janys, Dieter; Chang-Claude, Jenny.
in: BREAST, Jahrgang 22, Nr. 5, 01.10.2013, S. 817-23.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients--potential differential effects by radiotherapy?
AU - Seibold, Petra
AU - Hall, Per
AU - Schoof, Nils
AU - Nevanlinna, Heli
AU - Heikkinen, Tuomas
AU - Benner, Axel
AU - Liu, Jianjun
AU - Schmezer, Peter
AU - Popanda, Odilia
AU - Flesch-Janys, Dieter
AU - Chang-Claude, Jenny
N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.
PY - 2013/10/1
Y1 - 2013/10/1
N2 - We assessed whether variants in 22 oxidative stress-related genes are associated with mortality of breast cancer patients and whether the associations differ according to radiotherapy. Using a prospective cohort of 1348 postmenopausal breast cancer patients, we estimated hazard ratios (HR) and 95% confidence intervals (CI) for 109 single nucleotide polymorphisms (SNPs) using Cox proportional hazards regression. Validation of results was attempted using two Scandinavian studies. Eleven SNPs in MT2A, NFE2L2, NQO1, PRDX1, and PRDX6 were significantly associated with overall mortality after a median follow-up of 5.7 years. Three SNPs in NQO1 (rs2917667) and in PRDX6 (rs7314, rs4916362) were consistently associated with increased risk of dying across all three study populations (pooled: HRNQO1_rs2917667 1.20, 95% CI 1.00-1.44, p = 0.051; HRPRDX6_rs7314 1.16, 95% CI 1.00-1.35, p = 0.056, HRPRDX6_rs4916362 1.14 95% CI 1.00-1.32, p = 0.062). Potential effect modification by radiotherapy was found for CAT_rs769218. In conclusion, genetic variants in NQO1 and PRDX6 may modify breast cancer prognosis.
AB - We assessed whether variants in 22 oxidative stress-related genes are associated with mortality of breast cancer patients and whether the associations differ according to radiotherapy. Using a prospective cohort of 1348 postmenopausal breast cancer patients, we estimated hazard ratios (HR) and 95% confidence intervals (CI) for 109 single nucleotide polymorphisms (SNPs) using Cox proportional hazards regression. Validation of results was attempted using two Scandinavian studies. Eleven SNPs in MT2A, NFE2L2, NQO1, PRDX1, and PRDX6 were significantly associated with overall mortality after a median follow-up of 5.7 years. Three SNPs in NQO1 (rs2917667) and in PRDX6 (rs7314, rs4916362) were consistently associated with increased risk of dying across all three study populations (pooled: HRNQO1_rs2917667 1.20, 95% CI 1.00-1.44, p = 0.051; HRPRDX6_rs7314 1.16, 95% CI 1.00-1.35, p = 0.056, HRPRDX6_rs4916362 1.14 95% CI 1.00-1.32, p = 0.062). Potential effect modification by radiotherapy was found for CAT_rs769218. In conclusion, genetic variants in NQO1 and PRDX6 may modify breast cancer prognosis.
KW - Aged
KW - Aged, 80 and over
KW - Breast Neoplasms
KW - Catalase
KW - Female
KW - Genotype
KW - Histone Deacetylases
KW - Humans
KW - Kaplan-Meier Estimate
KW - Middle Aged
KW - NAD(P)H Dehydrogenase (Quinone)
KW - NF-E2-Related Factor 2
KW - Oxidative Stress
KW - Peroxiredoxin VI
KW - Peroxiredoxins
KW - Polymorphism, Single Nucleotide
KW - Prognosis
KW - Prospective Studies
KW - Repressor Proteins
U2 - 10.1016/j.breast.2013.02.008
DO - 10.1016/j.breast.2013.02.008
M3 - SCORING: Journal article
C2 - 23489758
VL - 22
SP - 817
EP - 823
JO - BREAST
JF - BREAST
SN - 0960-9776
IS - 5
ER -