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Platelets and vascular integrity

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Platelets and vascular integrity. / Deppermann, Carsten.

In: PLATELETS, Vol. 29, No. 6, 09.2018, p. 549-555.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Deppermann, C 2018, 'Platelets and vascular integrity', PLATELETS, vol. 29, no. 6, pp. 549-555. https://doi.org/10.1080/09537104.2018.1428739

APA

Deppermann, C. (2018). Platelets and vascular integrity. PLATELETS, 29(6), 549-555. https://doi.org/10.1080/09537104.2018.1428739

Vancouver

Deppermann C. Platelets and vascular integrity. PLATELETS. 2018 Sep;29(6):549-555. https://doi.org/10.1080/09537104.2018.1428739

Bibtex

@article{6596a5e6f3d0415a95882a606affc326,
title = "Platelets and vascular integrity",
abstract = "Platelets patrol the vasculature and adhere at sites of vascular damage after trauma to limit blood loss. In recent years, however, it has become clear that platelets also contribute to pathophysiologic processes such as thrombosis, atherosclerosis, stroke, sepsis and many more. An exciting new role for them is in non-classical hemostasis to prevent bleeding in the inflamed vasculature. Recent studies suggest that GPVI, CLEC-2, integrin αIIbβ3 (GPIIb/IIIa), and the content of platelet α- and dense granules are important players in this process. This review summarizes the current knowledge about how platelets prevent vascular integrity during inflammation in the skin, lung, and the ischemic brain and their organ-specific role.",
keywords = "Blood Platelets/immunology, Hemorrhage/etiology, Humans, Signal Transduction",
author = "Carsten Deppermann",
year = "2018",
month = sep,
doi = "10.1080/09537104.2018.1428739",
language = "English",
volume = "29",
pages = "549--555",
journal = "PLATELETS",
issn = "0953-7104",
publisher = "informa healthcare",
number = "6",

}

RIS

TY - JOUR

T1 - Platelets and vascular integrity

AU - Deppermann, Carsten

PY - 2018/9

Y1 - 2018/9

N2 - Platelets patrol the vasculature and adhere at sites of vascular damage after trauma to limit blood loss. In recent years, however, it has become clear that platelets also contribute to pathophysiologic processes such as thrombosis, atherosclerosis, stroke, sepsis and many more. An exciting new role for them is in non-classical hemostasis to prevent bleeding in the inflamed vasculature. Recent studies suggest that GPVI, CLEC-2, integrin αIIbβ3 (GPIIb/IIIa), and the content of platelet α- and dense granules are important players in this process. This review summarizes the current knowledge about how platelets prevent vascular integrity during inflammation in the skin, lung, and the ischemic brain and their organ-specific role.

AB - Platelets patrol the vasculature and adhere at sites of vascular damage after trauma to limit blood loss. In recent years, however, it has become clear that platelets also contribute to pathophysiologic processes such as thrombosis, atherosclerosis, stroke, sepsis and many more. An exciting new role for them is in non-classical hemostasis to prevent bleeding in the inflamed vasculature. Recent studies suggest that GPVI, CLEC-2, integrin αIIbβ3 (GPIIb/IIIa), and the content of platelet α- and dense granules are important players in this process. This review summarizes the current knowledge about how platelets prevent vascular integrity during inflammation in the skin, lung, and the ischemic brain and their organ-specific role.

KW - Blood Platelets/immunology

KW - Hemorrhage/etiology

KW - Humans

KW - Signal Transduction

U2 - 10.1080/09537104.2018.1428739

DO - 10.1080/09537104.2018.1428739

M3 - SCORING: Review article

C2 - 29446689

VL - 29

SP - 549

EP - 555

JO - PLATELETS

JF - PLATELETS

SN - 0953-7104

IS - 6

ER -