Platelets and vascular integrity
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Platelets and vascular integrity. / Deppermann, Carsten.
in: PLATELETS, Jahrgang 29, Nr. 6, 09.2018, S. 549-555.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Platelets and vascular integrity
AU - Deppermann, Carsten
PY - 2018/9
Y1 - 2018/9
N2 - Platelets patrol the vasculature and adhere at sites of vascular damage after trauma to limit blood loss. In recent years, however, it has become clear that platelets also contribute to pathophysiologic processes such as thrombosis, atherosclerosis, stroke, sepsis and many more. An exciting new role for them is in non-classical hemostasis to prevent bleeding in the inflamed vasculature. Recent studies suggest that GPVI, CLEC-2, integrin αIIbβ3 (GPIIb/IIIa), and the content of platelet α- and dense granules are important players in this process. This review summarizes the current knowledge about how platelets prevent vascular integrity during inflammation in the skin, lung, and the ischemic brain and their organ-specific role.
AB - Platelets patrol the vasculature and adhere at sites of vascular damage after trauma to limit blood loss. In recent years, however, it has become clear that platelets also contribute to pathophysiologic processes such as thrombosis, atherosclerosis, stroke, sepsis and many more. An exciting new role for them is in non-classical hemostasis to prevent bleeding in the inflamed vasculature. Recent studies suggest that GPVI, CLEC-2, integrin αIIbβ3 (GPIIb/IIIa), and the content of platelet α- and dense granules are important players in this process. This review summarizes the current knowledge about how platelets prevent vascular integrity during inflammation in the skin, lung, and the ischemic brain and their organ-specific role.
KW - Blood Platelets/immunology
KW - Hemorrhage/etiology
KW - Humans
KW - Signal Transduction
U2 - 10.1080/09537104.2018.1428739
DO - 10.1080/09537104.2018.1428739
M3 - SCORING: Review article
C2 - 29446689
VL - 29
SP - 549
EP - 555
JO - PLATELETS
JF - PLATELETS
SN - 0953-7104
IS - 6
ER -