Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure

Laura Michalick; Sarah Weidenfeld; Benjamin Grimmer; Diana Fatykhova; Philip Daniel Solymosi; Felix Behrens; Melanie Dohmen; Markus C Brack; Sabrina Schulz; Elisa Thomasch; Szandor Simmons; Holger Müller-Redetzky; Norbert Suttorp; Florian Kurth; Jens Neudecker; Mario Toennies; Torsten T Bauer; Stephan Eggeling; Victor Max Corman; Andreas C Hocke; Martin Witzenrath; Stefan Hippenstiel; Wolfgang M Kuebler

doi:10.1183/13993003.02384-2020

Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure

Laura Michalick
Sarah Weidenfeld
Benjamin Grimmer
Diana Fatykhova
Philip Daniel Solymosi
Felix Behrens
Melanie Dohmen
Markus C Brack
Sabrina Schulz
Elisa Thomasch
Szandor Simmons
Holger Müller-Redetzky
Norbert Suttorp
Florian Kurth
Jens Neudecker
Mario Toennies
Torsten T Bauer
Stephan Eggeling
Victor Max Corman
Andreas C Hocke
Martin Witzenrath
Stefan Hippenstiel (Shared last author)
Wolfgang M Kuebler (Shared last author)

Abstract

The plasma of COVID-19 patients induces pulmonary microvascular barrier failure, which increases with disease severity. Here, a screening platform to test for plasma mediators and the therapeutic potential of barrier stabilising compounds is reported. https://bit.ly/3k4C0tB

Bibliographical data

Original language	English
ISSN	0903-1936
DOIs	https://doi.org/10.1183/13993003.02384-2020
Publication status	Published - 03.2021
Externally published	Yes

PubMed	33154030