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Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease

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Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease. / Kubala, Lukas; Lu, Guijing; Baldus, Stephan; Berglund, Lars; Eiserich, Jason P.

In: CLIN CHIM ACTA, Vol. 394, No. 1-2, 08.2008, p. 59-62.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kubala, L, Lu, G, Baldus, S, Berglund, L & Eiserich, JP 2008, 'Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease', CLIN CHIM ACTA, vol. 394, no. 1-2, pp. 59-62. https://doi.org/10.1016/j.cca.2008.04.001

APA

Kubala, L., Lu, G., Baldus, S., Berglund, L., & Eiserich, J. P. (2008). Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease. CLIN CHIM ACTA, 394(1-2), 59-62. https://doi.org/10.1016/j.cca.2008.04.001

Vancouver

Kubala L, Lu G, Baldus S, Berglund L, Eiserich JP. Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease. CLIN CHIM ACTA. 2008 Aug;394(1-2):59-62. https://doi.org/10.1016/j.cca.2008.04.001

Bibtex

@article{ebe1ce43cf054133b733a020a97d3513,
title = "Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease",
abstract = "BACKGROUND: Plasma and serum levels of myeloperoxidase (MPO), a redox-active hemoprotein released by polymorphonuclear neutrophils (PMN) upon activation, is now recognized as a powerful prognostic determinant of myocardial infarction in patients suffering acute coronary syndromes. However, there is limited information on whether systemic MPO levels are also elevated and of discriminating value in patients with stable coronary artery disease (CAD) representing different ethnic groups.METHODS: Plasma levels of MPO and traditional CAD risk factors were quantified in African American and Caucasian patients (n=557) undergoing elective coronary angiography.RESULTS: MPO levels did not differ significantly between patients with or without CAD [421 pM (321, 533) vs. 412 pM (326, 500), p>0.05]. MPO levels were similar across ethnicity and gender, and correlated positively with CRP and fibrinogen levels (r=0.132, p=0.002 and r=0.106, p=0.011, respectively).CONCLUSION: In conclusion, plasma MPO levels were not elevated in patients with stable CAD, suggesting that systemic release of MPO is not a characteristic feature of asymptomatic CAD.",
keywords = "Aged, Coronary Artery Disease/blood, Female, Humans, Male, Middle Aged, Peroxidase/blood",
author = "Lukas Kubala and Guijing Lu and Stephan Baldus and Lars Berglund and Eiserich, {Jason P}",
year = "2008",
month = aug,
doi = "10.1016/j.cca.2008.04.001",
language = "English",
volume = "394",
pages = "59--62",
journal = "CLIN CHIM ACTA",
issn = "0009-8981",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease

AU - Kubala, Lukas

AU - Lu, Guijing

AU - Baldus, Stephan

AU - Berglund, Lars

AU - Eiserich, Jason P

PY - 2008/8

Y1 - 2008/8

N2 - BACKGROUND: Plasma and serum levels of myeloperoxidase (MPO), a redox-active hemoprotein released by polymorphonuclear neutrophils (PMN) upon activation, is now recognized as a powerful prognostic determinant of myocardial infarction in patients suffering acute coronary syndromes. However, there is limited information on whether systemic MPO levels are also elevated and of discriminating value in patients with stable coronary artery disease (CAD) representing different ethnic groups.METHODS: Plasma levels of MPO and traditional CAD risk factors were quantified in African American and Caucasian patients (n=557) undergoing elective coronary angiography.RESULTS: MPO levels did not differ significantly between patients with or without CAD [421 pM (321, 533) vs. 412 pM (326, 500), p>0.05]. MPO levels were similar across ethnicity and gender, and correlated positively with CRP and fibrinogen levels (r=0.132, p=0.002 and r=0.106, p=0.011, respectively).CONCLUSION: In conclusion, plasma MPO levels were not elevated in patients with stable CAD, suggesting that systemic release of MPO is not a characteristic feature of asymptomatic CAD.

AB - BACKGROUND: Plasma and serum levels of myeloperoxidase (MPO), a redox-active hemoprotein released by polymorphonuclear neutrophils (PMN) upon activation, is now recognized as a powerful prognostic determinant of myocardial infarction in patients suffering acute coronary syndromes. However, there is limited information on whether systemic MPO levels are also elevated and of discriminating value in patients with stable coronary artery disease (CAD) representing different ethnic groups.METHODS: Plasma levels of MPO and traditional CAD risk factors were quantified in African American and Caucasian patients (n=557) undergoing elective coronary angiography.RESULTS: MPO levels did not differ significantly between patients with or without CAD [421 pM (321, 533) vs. 412 pM (326, 500), p>0.05]. MPO levels were similar across ethnicity and gender, and correlated positively with CRP and fibrinogen levels (r=0.132, p=0.002 and r=0.106, p=0.011, respectively).CONCLUSION: In conclusion, plasma MPO levels were not elevated in patients with stable CAD, suggesting that systemic release of MPO is not a characteristic feature of asymptomatic CAD.

KW - Aged

KW - Coronary Artery Disease/blood

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Peroxidase/blood

U2 - 10.1016/j.cca.2008.04.001

DO - 10.1016/j.cca.2008.04.001

M3 - SCORING: Journal article

C2 - 18440308

VL - 394

SP - 59

EP - 62

JO - CLIN CHIM ACTA

JF - CLIN CHIM ACTA

SN - 0009-8981

IS - 1-2

ER -