Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease
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Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease. / Kubala, Lukas; Lu, Guijing; Baldus, Stephan; Berglund, Lars; Eiserich, Jason P.
in: CLIN CHIM ACTA, Jahrgang 394, Nr. 1-2, 08.2008, S. 59-62.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease
AU - Kubala, Lukas
AU - Lu, Guijing
AU - Baldus, Stephan
AU - Berglund, Lars
AU - Eiserich, Jason P
PY - 2008/8
Y1 - 2008/8
N2 - BACKGROUND: Plasma and serum levels of myeloperoxidase (MPO), a redox-active hemoprotein released by polymorphonuclear neutrophils (PMN) upon activation, is now recognized as a powerful prognostic determinant of myocardial infarction in patients suffering acute coronary syndromes. However, there is limited information on whether systemic MPO levels are also elevated and of discriminating value in patients with stable coronary artery disease (CAD) representing different ethnic groups.METHODS: Plasma levels of MPO and traditional CAD risk factors were quantified in African American and Caucasian patients (n=557) undergoing elective coronary angiography.RESULTS: MPO levels did not differ significantly between patients with or without CAD [421 pM (321, 533) vs. 412 pM (326, 500), p>0.05]. MPO levels were similar across ethnicity and gender, and correlated positively with CRP and fibrinogen levels (r=0.132, p=0.002 and r=0.106, p=0.011, respectively).CONCLUSION: In conclusion, plasma MPO levels were not elevated in patients with stable CAD, suggesting that systemic release of MPO is not a characteristic feature of asymptomatic CAD.
AB - BACKGROUND: Plasma and serum levels of myeloperoxidase (MPO), a redox-active hemoprotein released by polymorphonuclear neutrophils (PMN) upon activation, is now recognized as a powerful prognostic determinant of myocardial infarction in patients suffering acute coronary syndromes. However, there is limited information on whether systemic MPO levels are also elevated and of discriminating value in patients with stable coronary artery disease (CAD) representing different ethnic groups.METHODS: Plasma levels of MPO and traditional CAD risk factors were quantified in African American and Caucasian patients (n=557) undergoing elective coronary angiography.RESULTS: MPO levels did not differ significantly between patients with or without CAD [421 pM (321, 533) vs. 412 pM (326, 500), p>0.05]. MPO levels were similar across ethnicity and gender, and correlated positively with CRP and fibrinogen levels (r=0.132, p=0.002 and r=0.106, p=0.011, respectively).CONCLUSION: In conclusion, plasma MPO levels were not elevated in patients with stable CAD, suggesting that systemic release of MPO is not a characteristic feature of asymptomatic CAD.
KW - Aged
KW - Coronary Artery Disease/blood
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Peroxidase/blood
U2 - 10.1016/j.cca.2008.04.001
DO - 10.1016/j.cca.2008.04.001
M3 - SCORING: Journal article
C2 - 18440308
VL - 394
SP - 59
EP - 62
JO - CLIN CHIM ACTA
JF - CLIN CHIM ACTA
SN - 0009-8981
IS - 1-2
ER -