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Plasma kallikrein the bradykinin-producing enzyme

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Plasma kallikrein the bradykinin-producing enzyme. / Björkqvist, J; Jämsä, A; Renné, T.

In: THROMB HAEMOSTASIS, Vol. 110, No. 3, 01.09.2013, p. 399-407.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Björkqvist, J, Jämsä, A & Renné, T 2013, 'Plasma kallikrein the bradykinin-producing enzyme', THROMB HAEMOSTASIS, vol. 110, no. 3, pp. 399-407. https://doi.org/10.1160/TH13-03-0258

APA

Björkqvist, J., Jämsä, A., & Renné, T. (2013). Plasma kallikrein the bradykinin-producing enzyme. THROMB HAEMOSTASIS, 110(3), 399-407. https://doi.org/10.1160/TH13-03-0258

Vancouver

Björkqvist J, Jämsä A, Renné T. Plasma kallikrein the bradykinin-producing enzyme. THROMB HAEMOSTASIS. 2013 Sep 1;110(3):399-407. https://doi.org/10.1160/TH13-03-0258

Bibtex

@article{bef3b70784644b8e992cfa3323b5be9e,
title = "Plasma kallikrein the bradykinin-producing enzyme",
abstract = "Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The zymogen is converted to PK by activated factor XII. PK drives multiple proteolytic reaction cascades in the cardiovascular system such as the intrinsic pathway of coagulation, the kallikrein-kinin system, the fibrinolytic system, the renin-angiotensin system and the alternative complement pathway. Here, we review the biochemistry and cell biology of PK and focus on recent in vivo studies that have established important functions of the protease in procoagulant and proinflammatory disease states. Targeting PK offers novel strategies not previously appreciated to interfere with thrombosis and vascular inflammation in a broad variety of diseases.",
keywords = "Animals, Aprotinin, Blood Coagulation, Bradykinin, Cerebral Hemorrhage, Complement System Proteins, Cysteine, Diabetic Retinopathy, Disulfides, Factor XIIa, Fibrinolysis, Hemostasis, Humans, Inflammation, Kallikrein-Kinin System, Kallikreins, Kinins, Mice, Oligonucleotides, Antisense, Peptides, Plasma Kallikrein, Protein Structure, Tertiary, Proteolysis, Renin-Angiotensin System, Signal Transduction, Thrombosis, Trypsin",
author = "J Bj{\"o}rkqvist and A J{\"a}ms{\"a} and T Renn{\'e}",
year = "2013",
month = sep,
day = "1",
doi = "10.1160/TH13-03-0258",
language = "English",
volume = "110",
pages = "399--407",
journal = "THROMB HAEMOSTASIS",
issn = "0340-6245",
publisher = "Schattauer",
number = "3",

}

RIS

TY - JOUR

T1 - Plasma kallikrein the bradykinin-producing enzyme

AU - Björkqvist, J

AU - Jämsä, A

AU - Renné, T

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The zymogen is converted to PK by activated factor XII. PK drives multiple proteolytic reaction cascades in the cardiovascular system such as the intrinsic pathway of coagulation, the kallikrein-kinin system, the fibrinolytic system, the renin-angiotensin system and the alternative complement pathway. Here, we review the biochemistry and cell biology of PK and focus on recent in vivo studies that have established important functions of the protease in procoagulant and proinflammatory disease states. Targeting PK offers novel strategies not previously appreciated to interfere with thrombosis and vascular inflammation in a broad variety of diseases.

AB - Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The zymogen is converted to PK by activated factor XII. PK drives multiple proteolytic reaction cascades in the cardiovascular system such as the intrinsic pathway of coagulation, the kallikrein-kinin system, the fibrinolytic system, the renin-angiotensin system and the alternative complement pathway. Here, we review the biochemistry and cell biology of PK and focus on recent in vivo studies that have established important functions of the protease in procoagulant and proinflammatory disease states. Targeting PK offers novel strategies not previously appreciated to interfere with thrombosis and vascular inflammation in a broad variety of diseases.

KW - Animals

KW - Aprotinin

KW - Blood Coagulation

KW - Bradykinin

KW - Cerebral Hemorrhage

KW - Complement System Proteins

KW - Cysteine

KW - Diabetic Retinopathy

KW - Disulfides

KW - Factor XIIa

KW - Fibrinolysis

KW - Hemostasis

KW - Humans

KW - Inflammation

KW - Kallikrein-Kinin System

KW - Kallikreins

KW - Kinins

KW - Mice

KW - Oligonucleotides, Antisense

KW - Peptides

KW - Plasma Kallikrein

KW - Protein Structure, Tertiary

KW - Proteolysis

KW - Renin-Angiotensin System

KW - Signal Transduction

KW - Thrombosis

KW - Trypsin

U2 - 10.1160/TH13-03-0258

DO - 10.1160/TH13-03-0258

M3 - SCORING: Journal article

C2 - 23846131

VL - 110

SP - 399

EP - 407

JO - THROMB HAEMOSTASIS

JF - THROMB HAEMOSTASIS

SN - 0340-6245

IS - 3

ER -