Plasma kallikrein the bradykinin-producing enzyme
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Plasma kallikrein the bradykinin-producing enzyme. / Björkqvist, J; Jämsä, A; Renné, T.
in: THROMB HAEMOSTASIS, Jahrgang 110, Nr. 3, 01.09.2013, S. 399-407.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Plasma kallikrein the bradykinin-producing enzyme
AU - Björkqvist, J
AU - Jämsä, A
AU - Renné, T
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The zymogen is converted to PK by activated factor XII. PK drives multiple proteolytic reaction cascades in the cardiovascular system such as the intrinsic pathway of coagulation, the kallikrein-kinin system, the fibrinolytic system, the renin-angiotensin system and the alternative complement pathway. Here, we review the biochemistry and cell biology of PK and focus on recent in vivo studies that have established important functions of the protease in procoagulant and proinflammatory disease states. Targeting PK offers novel strategies not previously appreciated to interfere with thrombosis and vascular inflammation in a broad variety of diseases.
AB - Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The zymogen is converted to PK by activated factor XII. PK drives multiple proteolytic reaction cascades in the cardiovascular system such as the intrinsic pathway of coagulation, the kallikrein-kinin system, the fibrinolytic system, the renin-angiotensin system and the alternative complement pathway. Here, we review the biochemistry and cell biology of PK and focus on recent in vivo studies that have established important functions of the protease in procoagulant and proinflammatory disease states. Targeting PK offers novel strategies not previously appreciated to interfere with thrombosis and vascular inflammation in a broad variety of diseases.
KW - Animals
KW - Aprotinin
KW - Blood Coagulation
KW - Bradykinin
KW - Cerebral Hemorrhage
KW - Complement System Proteins
KW - Cysteine
KW - Diabetic Retinopathy
KW - Disulfides
KW - Factor XIIa
KW - Fibrinolysis
KW - Hemostasis
KW - Humans
KW - Inflammation
KW - Kallikrein-Kinin System
KW - Kallikreins
KW - Kinins
KW - Mice
KW - Oligonucleotides, Antisense
KW - Peptides
KW - Plasma Kallikrein
KW - Protein Structure, Tertiary
KW - Proteolysis
KW - Renin-Angiotensin System
KW - Signal Transduction
KW - Thrombosis
KW - Trypsin
U2 - 10.1160/TH13-03-0258
DO - 10.1160/TH13-03-0258
M3 - SCORING: Journal article
C2 - 23846131
VL - 110
SP - 399
EP - 407
JO - THROMB HAEMOSTASIS
JF - THROMB HAEMOSTASIS
SN - 0340-6245
IS - 3
ER -